Perspective articles are 800-1000 words, with up to 12 references, and they are aimed at general clinicians and clinical researchers worldwide (rather than specialists).
Please take readers through the following issues:
We want you to use a few sub-headings to guide readers through the piece.
You can see examples of PLOS Medicine Perspectives at:
Immunoprophylaxis against Mother-to-Child Transmission of HIV-1. Gorny MK, Zolla-Pazner S PLOS Medicine Vol. 3, No. 7, e259 http://dx.doi.org/10.1371/journal.pmed.0030259
Please use the following PLOS house style for references: (a) please number them at the end of the relevant sentence (e.g. "Inflammatory bowel diseases (IBD), characterized by chronic or recurrent relapsing gastrointestinal inflammation, are broadly grouped by clinical and pathological features into two groups—Crohn's disease and ulcerative colitis (UC) [6–8]."), and (b) In the numbered reference list at the end of the piece, the house style is "First five authors et al, year in parentheses, title, journal citation" (e.g. "Fadok VA, Bratton DL, Konowal A, Freed PW, Westcott JY, et al. (1998) Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J Clin Invest 101: 890–898.")
Finally, please include two statements with your article:
(a) Funding: Please state whether you received any specific funding to write your piece. If you did, please state whether the funder played any role in the article's preparation.
(b) Competing interests: Please state whether you have any competing interests related to the article (see http://www.plosmedicine.org/static/competing).