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Weekly Editors' Picks

Multiyear Climate Variability and Dengue - El Niño Southern Oscillation, Weather, and Dengue Incidence in Puerto Rico, Mexico, and Thailand: A Longitudinal Data Analysis

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Michael Johansson and colleagues use wavelet analysis to show that there is limited evidence for a multiyear relationship between climate and dengue incidence in Puerto Rico, Mexico, and Thailand. This article is discussed in a related Perspective by Pejman Rohani.

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The Unintended Consequences of Clinical Trials Regulations

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Alex McMahon and colleagues critique the International Conference on Harmonisation (ICH) guidance on good clinical practice (GCP), arguing that it is having a disastrous effect on noncommerical randomized clinical trials in Europe.

Image Credit: publik15

 

How Can We Support the Use of Systematic Reviews in Policymaking?

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John Lavis discusses how health policymakers and their stakeholders need research evidence, and suggests the best ways that evidence can be synthesized and packaged to optimize its use.

Image Credit: D'Arcy Norman

 

Health in Action

The Health in Action section focuses on innovative health improvement projects. These pieces are often written by health activists, non-governmental organizations, or researchers in low income settings. Recent Health in Action pieces have included Chand Khanna and colleagues' description of the work of the Comparative Oncology Trials Consortium (COTC), which provides infrastructure and resources to integrate naturally occurring dog cancer models into the development of new human cancer treatments. In addition, Penelope Enarson and colleagues described the development, scale-up, and achievements of a national pneumonia program in Malawi, based on a successful anti-tuberculosis service delivery model.

PLoS Medicine is a peer-reviewed, international, open-access journal publishing important original research and analysis relevant to human health.

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From the Web

Dengue is an increasingly prevalent mosquito-borne infection that causes a severe flu-like illness, and occurs mostly in the tropics and sub-tropics. There are over 100 million cases of dengue worldwide each year and currently no specific medication for the treatment of a dengue infection. The CDC site on dengue offers guidelines on how to prevent dengue, information on Aedes aegypti, the principal mosquito vector of dengue viruses, and news for travelers on dengue outbreaks. Many features of the site are also available in Spanish.

 
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