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Research Article

Reappraisal of Metformin Efficacy in the Treatment of Type 2 Diabetes: A Meta-Analysis of Randomised Controlled Trials

  • Rémy Boussageon,

    Affiliation: Department of General Medicine, Université Claude Bernard Lyon 1, Lyon, France

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  • Irène Supper,

    Affiliation: Department of General Medicine, Université Claude Bernard Lyon 1, Lyon, France

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  • Theodora Bejan-Angoulvant,

    Affiliations: Service de Pharmacologie Clinique, Centre Hospitalier Régional et Universitaire de Tours, France, UMR 7292, CNRS, Université François Rabelais, Tours, France

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  • Nadir Kellou,

    Affiliation: Department of General Medicine, Université Claude Bernard Lyon 1, Lyon, France

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  • Michel Cucherat,

    Affiliations: UMR 5558, CNRS, Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne, France, Université Claude Bernard Lyon 1, Lyon, France

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  • Jean-Pierre Boissel,

    Affiliations: UMR 5558, CNRS, Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne, France, Université Claude Bernard Lyon 1, Lyon, France

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  • Behrouz Kassai,

    Affiliations: UMR 5558, CNRS, Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne, France, Université Claude Bernard Lyon 1, Lyon, France, Clinical Investigation Centre, INSERM CIC201, Lyon, France, Department of Clinical Pharmacology, Hospices Civils de Lyon, Lyon, France

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  • Alain Moreau,

    Affiliation: Department of General Medicine, Université Claude Bernard Lyon 1, Lyon, France

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  • François Gueyffier,

    Affiliations: UMR 5558, CNRS, Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne, France, Université Claude Bernard Lyon 1, Lyon, France, Clinical Investigation Centre, INSERM CIC201, Lyon, France, Department of Clinical Pharmacology, Hospices Civils de Lyon, Lyon, France

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  • Catherine Cornu mail

    catherine.cornu@chu-lyon.fr

    Affiliations: UMR 5558, CNRS, Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne, France, Université Claude Bernard Lyon 1, Lyon, France, Clinical Investigation Centre, INSERM CIC201, Lyon, France, Department of Clinical Pharmacology, Hospices Civils de Lyon, Lyon, France

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  • Published: April 10, 2012
  • DOI: 10.1371/journal.pmed.1001204

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