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Research Article

Number of Patients Studied Prior to Approval of New Medicines: A Database Analysis

  • Ruben G. Duijnhoven,

    Affiliations: Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands, Medicines Evaluation Board, Utrecht, the Netherlands

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  • Sabine M. J. M. Straus,

    Affiliations: Medicines Evaluation Board, Utrecht, the Netherlands, Department of Medical Informatics, Erasmus Medical Center, Rotterdam, the Netherlands

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  • June M. Raine,

    Affiliation: Medicines and Healthcare products Regulatory Agency, London, United Kingdom

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  • Anthonius de Boer,

    Affiliation: Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands

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  • Arno W. Hoes,

    Affiliation: Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands

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  • Marie L. De Bruin mail

    M.L.DeBruin@uu.nl

    Affiliations: Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands, Medicines Evaluation Board, Utrecht, the Netherlands

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  • Published: March 19, 2013
  • DOI: 10.1371/journal.pmed.1001407

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