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Research Article

Whole Genome Sequencing versus Traditional Genotyping for Investigation of a Mycobacterium tuberculosis Outbreak: A Longitudinal Molecular Epidemiological Study

  • Andreas Roetzer equal contributor,

    equal contributor Contributed equally to this work with: Andreas Roetzer, Roland Diel, Thomas A. Kohl

    Affiliation: Molecular Mycobacteriology, Forschungszentrum Borstel, Borstel, Germany

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  • Roland Diel equal contributor,

    equal contributor Contributed equally to this work with: Andreas Roetzer, Roland Diel, Thomas A. Kohl

    Affiliation: Institute for Epidemiology, Schleswig-Holstein University Hospital, Kiel, Germany

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  • Thomas A. Kohl equal contributor,

    equal contributor Contributed equally to this work with: Andreas Roetzer, Roland Diel, Thomas A. Kohl

    Affiliations: Molecular Mycobacteriology, Forschungszentrum Borstel, Borstel, Germany, Institute for Genome Research and Systems Biology, CeBiTec, Bielefeld University, Bielefeld, Germany

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  • Christian Rückert,

    Affiliation: Institute for Genome Research and Systems Biology, CeBiTec, Bielefeld University, Bielefeld, Germany

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  • Ulrich Nübel,

    Affiliation: Robert Koch Institut, Wernigerode, Germany

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  • Jochen Blom,

    Affiliation: Computational Genomics, CeBiTec, Bielefeld University, Bielefeld, Germany

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  • Thierry Wirth,

    Affiliation: Department of Systematics and Evolution, Muséum National d'Histoire Naturelle, École Pratique des Hautes Études, Paris, France

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  • Sebastian Jaenicke,

    Affiliation: Computational Genomics, CeBiTec, Bielefeld University, Bielefeld, Germany

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  • Sieglinde Schuback,

    Affiliation: Gesundheitsamt des Kreises Steinburg, Itzehoe, Germany

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  • Sabine Rüsch-Gerdes,

    Affiliation: National Reference Center for Mycobacteria, Forschungszentrum Borstel, Borstel, Germany

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  • Philip Supply,

    Affiliation: INSERM, U1019, CNRS UMR 8204, Institut Pasteur de Lille, Univ Lille Nord de France, Lille, France

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  • Jörn Kalinowski,

    Affiliation: Institute for Genome Research and Systems Biology, CeBiTec, Bielefeld University, Bielefeld, Germany

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  • Stefan Niemann mail

    sniemann@fz-borstel.de

    Affiliation: Molecular Mycobacteriology, Forschungszentrum Borstel, Borstel, Germany

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  • Published: February 12, 2013
  • DOI: 10.1371/journal.pmed.1001387

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