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Research Article

Multidrug Resistant Pulmonary Tuberculosis Treatment Regimens and Patient Outcomes: An Individual Patient Data Meta-analysis of 9,153 Patients

  • Shama D. Ahuja,

    Affiliation: Bureau of Tuberculosis, New York, New York, United States of America

    X
  • David Ashkin,

    Affiliation: A.G. Holley Hospital, Lantana, Florida, United States of America

    X
  • Monika Avendano,

    Affiliation: University of Toronto, Toronto, Canada

    X
  • Rita Banerjee,

    Affiliation: Mayo Clinic, Rochester, Minnesota, United States of America

    X
  • Melissa Bauer,

    Affiliation: Montreal Chest Institute, McGill University, Montreal, Canada

    X
  • Jamie N. Bayona,

    Affiliation: The Dartmouth Center for Health Care Delivery Science, Hanover, New Hampshire, United States of America

    X
  • Mercedes C. Becerra,

    Affiliations: Harvard Medical School, Boston, Massachusetts, United States of America, Partners in Health, Boston, Massachusetts, United States of America

    X
  • Andrea Benedetti,

    Affiliation: Montreal Chest Institute, McGill University, Montreal, Canada

    X
  • Marcos Burgos,

    Affiliation: University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America

    X
  • Rosella Centis,

    Affiliation: WHO Collaborating Centre for TB and Lung Diseases, Care and Research Institute, Fondazione S. Maugeri, Tradate, Italy

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  • Eward D. Chan,

    Affiliation: Denver Veterans Affair Medical Center, Denver, Colorado, United States of America

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  • Chen-Yuan Chiang,

    Affiliation: Wan Fang Hospital, School of Medicine-Taipei Medical University, Taiwan

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  • Helen Cox,

    Affiliation: Médecins Sans Frontières, Capetown, South Africa

    X
  • Lia D'Ambrosio,

    Affiliation: WHO Collaborating Centre for TB and Lung Diseases, Care and Research Institute, Fondazione S. Maugeri, Tradate, Italy

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  • Kathy DeRiemer,

    Affiliation: UC Davis School of Medicine, Davis, California, United States of America

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  • Nguyen Huy Dung,

    Affiliation: National TB Control Program, Hanoi, Vietnam

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  • Donald Enarson,

    Affiliation: International Union against Tuberculosis and Lung Disease, Paris, France

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  • Dennis Falzon,

    Affiliation: World Health Organization, Geneva, Switzerland

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  • Katherine Flanagan,

    Affiliation: MRC Laboratories, Banjul, The Gambia

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  • Jennifer Flood,

    Affiliation: California Department of Public Health, Sacramento, California, United States of America

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  • Maria L. Garcia-Garcia,

    Affiliation: Instituto Nacional de Salud Pública, Mexico, Mexico

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  • Neel Gandhi,

    Affiliation: Albert Einstein College of Medicine, Bronx, New York, United States of America

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  • Reuben M. Granich,

    Affiliation: World Health Organization, Geneva, Switzerland

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  • Maria G. Hollm-Delgado,

    Affiliation: Montreal Chest Institute, McGill University, Montreal, Canada

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  • Timothy H. Holtz,

    Affiliation: Thailand MOPH & US CDC Collaboration, Bangkok, Thailand

    X
  • Michael D. Iseman,

    Affiliation: National Jewish Health, Denver, Colorado, United States of America

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  • Leah G. Jarlsberg,

    Affiliation: University of California, San Francisco, San Francisco, United States of America

    X
  • Salmaan Keshavjee,

    Affiliation: Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Hye-Ryoun Kim,

    Affiliation: Korea Cancer Center Hospital, Seoul, Korea

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  • Won-Jung Koh,

    Affiliation: Samsung Medical Center, Seoul, Korea

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  • Joey Lancaster,

    Affiliation: South African Medical Research Council, Pretoria, South Africa

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  • Christophe Lange,

    Affiliation: Medical Clinic, Tuberculosis Center Borstel, Borstel, Germany

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  • Wiel C. M. de Lange,

    Affiliation: University Medical Center Groningen, Groningen, The Netherlands

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  • Vaira Leimane,

    Affiliation: Clinic of Tuberculosis and Lung Diseases, Riga, Latvia

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  • Chi Chiu Leung,

    Affiliation: Tuberculosis and Chest Services, Hong Kong

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  • Jiehui Li,

    Affiliation: New York City Health and Mental Hygiene, New York, New York, United States of America

    X
  • Dick Menzies mail,

    Dick.Menzies@McGill.ca

    Affiliation: Montreal Chest Institute, McGill University, Montreal, Canada

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  • Giovanni B. Migliori,

    Affiliation: WHO Collaborating Centre for TB and Lung Diseases, Care and Research Institute, Fondazione S. Maugeri, Tradate, Italy

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  • Sergey P. Mishustin,

    Affiliation: Tomsk Oblast Tuberculosis Dispensary, Tomsk, Russia

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  • Carole D. Mitnick,

    Affiliation: Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Masa Narita,

    Affiliation: University of Washington, Seattle, Washington, United States of America

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  • Philly O'Riordan,

    Affiliation: City Road Medical Centre, London, United Kingdom

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  • Madhukar Pai,

    Affiliation: Montreal Chest Institute, McGill University, Montreal, Canada

    X
  • Domingo Palmero,

    Affiliation: Hospital F.J. Muñiz, Buenos Aires, Argentina

    X
  • Seung-kyu Park,

    Affiliation: TB Center, Seoul, Korea

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  • Geoffrey Pasvol,

    Affiliation: Imperial College London, London, United Kingdom

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  • Jose Peña,

    Affiliation: Universidad Autonoma Madrid, Madrid, Spain

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  • Carlos Pérez-Guzmán,

    Affiliation: Instituto de Salud del Estado de Aguascalientes, Mexico, Mexico

    X
  • Maria I. D. Quelapio,

    Affiliation: Tropical Disease Foundation, Makati City, Philippines

    X
  • Alfredo Ponce-de-Leon,

    Affiliation: Instituto Nacional de Ciencias Médicas y de Nutrición “Salvador Zubirán”, Mexico, Mexico

    X
  • Vija Riekstina,

    Affiliation: Clinic of Tuberculosis and Lung Diseases, Riga, Latvia

    X
  • Jerome Robert,

    Affiliation: Bactériologie-Hygiène – UPMC, Paris, France

    X
  • Sarah Royce,

    Affiliation: University of California, San Francisco, San Francisco, United States of America

    X
  • H. Simon Schaaf,

    Affiliation: Stellenbosch University, Stellenbosch, South Africa

    X
  • Kwonjune J. Seung,

    Affiliation: Brigham and Women's Hospital, Boston, Massachusetts, United States of America

    X
  • Lena Shah,

    Affiliation: Montreal Chest Institute, McGill University, Montreal, Canada

    X
  • Tae Sun Shim,

    Affiliation: University of Ulsan College of Medicine, Seoul, Korea

    X
  • Sonya S. Shin,

    Affiliation: Brigham and Women's Hospital, Boston, Massachusetts, United States of America

    X
  • Yuji Shiraishi,

    Affiliation: Fukujuji Hospital, Tokyo, Japan

    X
  • José Sifuentes-Osornio,

    Affiliation: Instituto Nacional de Ciencias Médicas y de Nutrición “Salvador Zubirán”, Mexico, Mexico

    X
  • Giovanni Sotgiu,

    Affiliation: University of Sassari, Sassari, Italy

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  • Matthew J. Strand,

    Affiliation: National Jewish Health, Denver, Colorado, United States of America

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  • Payam Tabarsi,

    Affiliation: Shaheed Beheshti Medical University, Tehran, Iran

    X
  • Thelma E. Tupasi,

    Affiliation: Tropical Disease Foundation, Makati City, Philippines

    X
  • Robert van Altena,

    Affiliation: University Medical Center Groningen, Groningen, The Netherlands

    X
  • Martie Van der Walt,

    Affiliation: South African Medical Research Council, Pretoria, South Africa

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  • Tjip S. Van der Werf,

    Affiliation: University Medical Center Groningen, Groningen, The Netherlands

    X
  • Mario H. Vargas,

    Affiliation: Instituto Nacional de Enfermedades Respiratorias, Mexico, Mexico

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  • Pirett Viiklepp,

    Affiliation: National Institute for Health Development, Tallinn, Estonia

    X
  • Janice Westenhouse,

    Affiliation: Center for Infectious Diseases-California Department of Public Health, Sacramento, California, United States of America

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  • Wing Wai Yew,

    Affiliation: Grantham Hospital, Hong Kong

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  • Jae-Joon Yim, on behalf of the Collaborative Group for Meta-Analysis of Individual Patient Data in MDR-TB,

    Affiliation: Seoul National University College of Medicine, Seoul, Korea

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  • Shama D. Ahuja

    All members of the Collaborative Group for Meta-Analysis of Individual Patient Data in MDR-TB are the authors and are listed in the manuscript byline.

    X
  • Published: August 28, 2012
  • DOI: 10.1371/journal.pmed.1001300

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Linked Articles

Correction: Multidrug Resistant Pulmonary Tuberculosis Treatment Regimens and Patient Outcomes: An Individual Patient Data Meta-analysis of 9,153 Patients

Shama D. Ahuja, David Ashkin, Monika Avendano, Rita Banerjee, Melissa Bauer, Jamie N. Bayona, Mercedes C. Becerra, Andrea Benedetti, Marcos Burgos, Rosella Centis, Eward D. Chan, ...
Correction | published 14 Sep 2012 | PLOS Medicine
doi:10.1371/annotation/230240bc-bcf3-46b2-9b21-2e6e584f7333