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Research Article

Induction of Labor versus Expectant Management in Women with Preterm Prelabor Rupture of Membranes between 34 and 37 Weeks: A Randomized Controlled Trial

  • David P. van der Ham mail,

    dpvanderham@gmail.com

    Affiliation: Department of Obstetrics and Gynecology, Maastricht University Medical Center, GROW—School for Oncology and Developmental Biology, Maastricht, The Netherlands

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  • Sylvia M. C. Vijgen,

    Affiliation: Department of Obstetrics and Gynecology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands

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  • Jan G. Nijhuis,

    Affiliation: Department of Obstetrics and Gynecology, Maastricht University Medical Center, GROW—School for Oncology and Developmental Biology, Maastricht, The Netherlands

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  • Johannes J. van Beek,

    Affiliation: Department of Obstetrics and Gynecology, VieCuri Medical Center, Venlo, The Netherlands

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  • Brent C. Opmeer,

    Affiliation: Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center Amsterdam, Amsterdam, The Netherlands

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  • Antonius L. M. Mulder,

    Affiliation: Department of Pediatrics, Maastricht University Medical Center, GROW—School for Oncology and Developmental Biology, Maastricht, The Netherlands

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  • Rob Moonen,

    Affiliation: Department of Pediatrics, Atrium Medical Center, Heerlen, The Netherlands

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  • Mariët Groenewout,

    Affiliation: Department of Obstetrics and Gynecology, University Medical Center Groningen, Groningen, The Netherlands

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  • Mariëlle G. van Pampus,

    Affiliation: Department of Obstetrics and Gynecology, University Medical Center Groningen, Groningen, The Netherlands

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  • Gerald D. Mantel,

    Affiliation: Department of Obstetrics and Gynecology, Isala Klinieken, Zwolle, The Netherlands

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  • Kitty W. M. Bloemenkamp,

    Affiliation: Department of Obstetrics and Gynecology, Leiden University Medical Center, Leiden, The Netherlands

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  • Wim J. van Wijngaarden,

    Affiliation: Department of Obstetrics and Gynecology, Bronovo Hospital, The Hague, The Netherlands

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  • Marko Sikkema,

    Affiliation: Department of Obstetrics and Gynecology, Ziekenhuisgroep Twente, Almelo, The Netherlands

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  • Monique C. Haak,

    Affiliation: Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands

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  • Paula J. M. Pernet,

    Affiliation: Department of Obstetrics and Gynecology, Kennemer Gasthuis, Haarlem, The Netherlands

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  • Martina Porath,

    Affiliation: Department of Obstetrics and Gynecology, Maxima Medical Center, Veldhoven, The Netherlands

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  • Jan F. M. Molkenboer,

    Affiliation: Department of Obstetrics and Gynecology, Sint Anna Hospital, Geldrop, The Netherlands

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  • Simone Kuppens,

    Affiliation: Department of Obstetrics and Gynecology, Catharina Hospital, Eindhoven, The Netherlands

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  • Anneke Kwee,

    Affiliation: Department of Obstetrics and Gynecology, University Medical Center, Utrecht, The Netherlands

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  • Michael E. Kars,

    Affiliation: Department of Obstetrics and Gynecology, Sint Antonius Hospital, Nieuwegein, The Netherlands

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  • Mallory Woiski,

    Affiliation: Department of Obstetrics and Gynecology, Sint Radboud University Medical Center, Nijmegen, The Netherlands

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  • Martin J. N. Weinans,

    Affiliation: Department of Obstetrics and Gynecology, Gelderse Vallei Hospital, Ede, The Netherlands

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  • Hajo I. J. Wildschut,

    Affiliation: Department of Obstetrics and Gynecology, Erasmus Medical Center, Rotterdam, The Netherlands

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  • Bettina M. C. Akerboom,

    Affiliation: Department of Obstetrics and Gynecology, Albert Schweitzer Hospital, Dordrecht, The Netherlands

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  • Ben W. J. Mol,

    Affiliation: Department of Obstetrics and Gynecology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands

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  • Christine Willekes,

    Affiliation: Department of Obstetrics and Gynecology, Maastricht University Medical Center, GROW—School for Oncology and Developmental Biology, Maastricht, The Netherlands

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  • on behalf of the PPROMEXIL trial group

    The PPROMEXIL trial group collaborators are listed in the Acknowledgments.

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  • Published: April 24, 2012
  • DOI: 10.1371/journal.pmed.1001208

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