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Research Article

Homocysteine and Coronary Heart Disease: Meta-analysis of MTHFR Case-Control Studies, Avoiding Publication Bias

  • Robert Clarke equal contributor mail,

    equal contributor Contributed equally to this work with: Robert Clarke, Derrick A. Bennett, Sarah Parish, Rory Collins, Richard Peto

    Robert.Clarke@ctsu.ox.ac.uk

    Affiliation: Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, Oxford, United Kingdom

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  • Derrick A. Bennett equal contributor,

    equal contributor Contributed equally to this work with: Robert Clarke, Derrick A. Bennett, Sarah Parish, Rory Collins, Richard Peto

    Affiliation: Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, Oxford, United Kingdom

    X
  • Sarah Parish equal contributor,

    equal contributor Contributed equally to this work with: Robert Clarke, Derrick A. Bennett, Sarah Parish, Rory Collins, Richard Peto

    Affiliation: Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, Oxford, United Kingdom

    X
  • Petra Verhoef,

    Affiliation: Unilever Research and Development, Vlaardingen, The Netherlands

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  • Mariska Dötsch-Klerk,

    Affiliation: Unilever Research and Development, Vlaardingen, The Netherlands

    X
  • Mark Lathrop,

    Affiliation: Centre National de Genotypage, Evry, France

    X
  • Peng Xu,

    Affiliation: Centre National de Genotypage, Evry, France

    X
  • Børge G. Nordestgaard,

    Affiliation: Herlev Hospital Department of Clinical Biochemistry, University of Copenhagen, Copenhagen, Denmark

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  • Hilma Holm,

    Affiliation: deCODE Inc, Rejkavik, Iceland

    X
  • Jemma C. Hopewell,

    Affiliation: Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, Oxford, United Kingdom

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  • Danish Saleheen,

    Affiliations: Department of Public Health and Primary Care, University of Cambridge, United Kingdom, Center for Non-Communicable Diseases, Karachi, Pakistan

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  • Toshihiro Tanaka,

    Affiliation: RIKEN Centre for Genomic Medicine, Yokohama, Japan

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  • Sonia S. Anand,

    Affiliation: Population Health Research Institute, Hamilton, Canada

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  • John C. Chambers,

    Affiliation: Imperial College Faculty of Medicine, University of London, London, United Kingdom

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  • Marcus E. Kleber,

    Affiliation: Luric Study Non-Profit LCC, University of Freiburg, Freiburg, Germany

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  • Willem H. Ouwehand,

    Affiliation: Department of Haematology, University of Cambridge, United Kingdom

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  • Yoshiji Yamada,

    Affiliation: Mie University Life Science Research Center, Tsu, Japan

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  • Clara Elbers,

    Affiliation: Department of Medical Genetics, University of Utrecht, Utrecht, The Netherlands

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  • Bas Peters,

    Affiliation: Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, The Netherlands

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  • Alexandre F. R. Stewart,

    Affiliation: Heart Institute, University of Ottawa, Ottawa, Canada

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  • Muredach M. Reilly,

    Affiliation: Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Barbara Thorand,

    Affiliation: Helmholtz Zentrum, Institute of Epidemiology II, German Research Center for Environmental Health, Munich, Germany

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  • Salim Yusuf,

    Affiliation: Population Health Research Institute, Hamilton, Canada

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  • James C. Engert,

    Affiliation: McGill University Health Centre, Montreal, Canada

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  • Themistocles L. Assimes,

    Affiliation: Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America

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  • Jaspal Kooner,

    Affiliation: Imperial College Faculty of Medicine, University of London, London, United Kingdom

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  • John Danesh,

    Affiliation: Department of Public Health and Primary Care, University of Cambridge, United Kingdom

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  • Hugh Watkins,

    Affiliation: Department of Cardiovascular Medicine, University of Oxford, United Kingdom

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  • Nilesh J. Samani,

    Affiliation: Department of Cardiovascular Sciences, University of Leicester, United Kingdom

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  • Rory Collins equal contributor,

    equal contributor Contributed equally to this work with: Robert Clarke, Derrick A. Bennett, Sarah Parish, Rory Collins, Richard Peto

    Affiliation: Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, Oxford, United Kingdom

    X
  • Richard Peto equal contributor,

    equal contributor Contributed equally to this work with: Robert Clarke, Derrick A. Bennett, Sarah Parish, Rory Collins, Richard Peto

    Affiliation: Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, Oxford, United Kingdom

    X
  • for the MTHFR Studies Collaborative Group

    Membership of the MTHFR Studies Collaborative Group is provided in the Acknowledgments.

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  • Published: February 21, 2012
  • DOI: 10.1371/journal.pmed.1001177

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