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Research Article

The Effect of Chromosome 9p21 Variants on Cardiovascular Disease May Be Modified by Dietary Intake: Evidence from a Case/Control and a Prospective Study

  • Ron Do,

    Affiliation: Department of Human Genetics, McGill University, Montréal, Quebec, Canada

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  • Changchun Xie,

    Affiliations: Population Health Research Institute, Hamilton Health Sciences, and McMaster University, Hamilton, Ontario, Canada, Departments of Medicine and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada

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  • Xiaohe Zhang,

    Affiliation: Population Health Research Institute, Hamilton Health Sciences, and McMaster University, Hamilton, Ontario, Canada

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  • Satu Männistö,

    Affiliation: Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

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  • Kennet Harald,

    Affiliation: Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

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  • Shofiqul Islam,

    Affiliations: Population Health Research Institute, Hamilton Health Sciences, and McMaster University, Hamilton, Ontario, Canada, Departments of Medicine and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada

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  • Swneke D. Bailey,

    Affiliation: Department of Human Genetics, McGill University, Montréal, Quebec, Canada

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  • Sumathy Rangarajan,

    Affiliation: Population Health Research Institute, Hamilton Health Sciences, and McMaster University, Hamilton, Ontario, Canada

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  • Matthew J. McQueen,

    Affiliation: Population Health Research Institute, Hamilton Health Sciences, and McMaster University, Hamilton, Ontario, Canada

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  • Rafael Diaz,

    Affiliation: Estudios Cardiologicos Latinoamerica, Rosario, Argentina

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  • Liu Lisheng,

    Affiliation: Cardiovascular Institute and Fu Wai Hospital, Chinese Hypertension League Institute, Beijing, China

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  • Xingyu Wang,

    Affiliation: Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing, China

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  • Kaisa Silander,

    Affiliations: Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Human Genomics Unit, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland

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  • Leena Peltonen †,

    † Deceased.

    Affiliations: Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Human Genomics Unit, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland

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  • Salim Yusuf,

    Affiliation: Population Health Research Institute, Hamilton Health Sciences, and McMaster University, Hamilton, Ontario, Canada

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  • Veikko Salomaa,

    Affiliation: Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

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  • James C. Engert mail,

    jamie.engert@mcgill.ca (JCE); anands@mcmaster.ca (SSA)

    Affiliations: Department of Human Genetics, McGill University, Montréal, Quebec, Canada, Department of Medicine, McGill University, Montréal, Quebec, Canada, The Research Institute of the McGill University Health Centre, Montréal, Quebec, Canada

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  • Sonia S. Anand mail,

    jamie.engert@mcgill.ca (JCE); anands@mcmaster.ca (SSA)

    Affiliations: Population Health Research Institute, Hamilton Health Sciences, and McMaster University, Hamilton, Ontario, Canada, Departments of Medicine and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada

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  • on behalf of the INTERHEART investigators
  • Published: October 11, 2011
  • DOI: 10.1371/journal.pmed.1001106

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