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Research Article

IL28B, HLA-C, and KIR Variants Additively Predict Response to Therapy in Chronic Hepatitis C Virus Infection in a European Cohort: A Cross-Sectional Study

  • Vijayaprakash Suppiah,

    Affiliations: Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Sydney, Australia, Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia

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  • Silvana Gaudieri,

    Affiliation: Institute for Infectious Diseases, Murdoch University, Perth, Australia

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  • Nicola J. Armstrong,

    Affiliations: Cancer Research Program, Garvan Institute for Medical Research, University of New South Wales, Sydney, Australia, School of Mathematics and Statistics, University of New South Wales, Sydney, Australia

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  • Kate S. O'Connor,

    Affiliation: Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia

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  • Thomas Berg,

    Affiliations: Medizinische Klinik m.S. Hepatologie und Gastroenterologie, Charité, Campus Virchow-Klinikum, Universitätsmedizin Berlin, Germany, Department of Hepatology, Clinic for Gastroenterology and Rheumatology, University Clinic Leipzig, Leipzig, Germany

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  • Martin Weltman,

    Affiliation: Department of Gastroenterology and Hepatology, Nepean Hospital, Sydney, Australia

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  • Maria Lorena Abate,

    Affiliation: Liver Physiopathology Lab, Department of Internal Medicine, University of Turin, Turin, Italy

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  • Ulrich Spengler,

    Affiliation: Department of Internal Medicine I, University of Bonn, Bonn, Germany

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  • Margaret Bassendine,

    Affiliation: Liver Research Group, Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom

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  • Gregory J. Dore,

    Affiliations: National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia, St Vincent's Hospital, Sydney, Australia

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  • William L. Irving,

    Affiliation: NIHR Biomedical Research Unit in Gastroenterology and the Liver, University of Nottingham, Nottingham, United Kingdom

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  • Elizabeth Powell,

    Affiliations: Princess Alexandra Hospital, Department of Gastroenterology and Hepatology, Woolloongabba, The University of Queensland, School of Medicine, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia

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  • Margaret Hellard,

    Affiliation: Burnet Institute, Commercial Road, Melbourne, Victoria, Australia

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  • Stephen Riordan,

    Affiliation: Gastrointestinal and Liver Unit, Prince of Wales Hospital and University of New South Wales, Sydney, Australia

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  • Gail Matthews,

    Affiliations: National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia, St Vincent's Hospital, Sydney, Australia

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  • David Sheridan,

    Affiliation: Liver Research Group, Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom

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  • Jacob Nattermann,

    Affiliation: Department of Internal Medicine I, University of Bonn, Bonn, Germany

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  • Antonina Smedile,

    Affiliation: Liver Physiopathology Lab, Department of Internal Medicine, University of Turin, Turin, Italy

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  • Tobias Müller,

    Affiliations: Medizinische Klinik m.S. Hepatologie und Gastroenterologie, Charité, Campus Virchow-Klinikum, Universitätsmedizin Berlin, Germany, Department of Hepatology, Clinic for Gastroenterology and Rheumatology, University Clinic Leipzig, Leipzig, Germany

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  • Emma Hammond,

    Affiliation: Institute for Infectious Diseases, Murdoch University, Perth, Australia

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  • David Dunn,

    Affiliation: Institute for Infectious Diseases, Murdoch University, Perth, Australia

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  • Francesco Negro,

    Affiliation: Divisions of Gastroenterology, Hepatology, and Clinical Pathology, University Hospitals Geneva, Switzerland

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  • Pierre-Yves Bochud,

    Affiliation: Divisions of Gastroenterology, Hepatology, and Clinical Pathology, University Hospitals Geneva, Switzerland

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  • Simon Mallal,

    Affiliation: Institute for Infectious Diseases, Murdoch University, Perth, Australia

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  • Golo Ahlenstiel,

    Affiliation: Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Sydney, Australia

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  • Graeme J. Stewart,

    Affiliation: Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia

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  • Jacob George,

    Affiliation: Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Sydney, Australia

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  • David R. Booth mail,

    david_booth@wmi.usyd.edu.au

    Affiliation: Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia

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  • for the International Hepatitis C Genetics Consortium (IHCGC)

    Contributing members of the International Hepatitis C Genetics Consortium (IHCGC) are listed in the Acknowledgments.

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  • Published: September 13, 2011
  • DOI: 10.1371/journal.pmed.1001092

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