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Research Article

Low-Dose Adrenaline, Promethazine, and Hydrocortisone in the Prevention of Acute Adverse Reactions to Antivenom following Snakebite: A Randomised, Double-Blind, Placebo-Controlled Trial

  • H. Asita de Silva mail,

    asita@sltnet.lk

    Affiliation: Clinical Trials Unit, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka

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  • Arunasalam Pathmeswaran,

    Affiliation: Clinical Trials Unit, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka

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  • Channa D. Ranasinha,

    Affiliation: Clinical Trials Unit, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka

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  • Shaluka Jayamanne,

    Affiliation: Polonnaruwa General Hospital, Polonnaruwa, Sri Lanka

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  • Senarath B. Samarakoon,

    Affiliation: Polonnaruwa General Hospital, Polonnaruwa, Sri Lanka

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  • Ariyasena Hittharage,

    Affiliation: Kurunegala Teaching Hospital, Kurunegala, Sri Lanka

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  • Ranjith Kalupahana,

    Affiliation: Kurunegala Teaching Hospital, Kurunegala, Sri Lanka

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  • G. Asoka Ratnatilaka,

    Affiliation: Kurunegala Teaching Hospital, Kurunegala, Sri Lanka

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  • Wimalasiri Uluwatthage,

    Affiliation: Hambantota General Hospital, Hambantota, Sri Lanka

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  • Jeffrey K. Aronson,

    Affiliation: Department of Primary Health Care, University of Oxford, Oxford, United Kingdom

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  • Jane M. Armitage,

    Affiliation: Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom

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  • David G. Lalloo,

    Affiliation: Liverpool School of Tropical Medicine, Liverpool, United Kingdom

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  • H. Janaka de Silva

    Affiliation: Clinical Trials Unit, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka

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  • Published: May 10, 2011
  • DOI: 10.1371/journal.pmed.1000435

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