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Research Article

Analysis of Germline GLI1 Variation Implicates Hedgehog Signalling in the Regulation of Intestinal Inflammatory Pathways

  • Charlie W Lees equal contributor mail,

    equal contributor Contributed equally to this work with: Charlie W Lees, William J Zacharias

    To whom correspondence should be addressed. E-mail: Charlie.lees@ed.ac.uk (CWL); dgumucio@umich.edu (DLG)

    Affiliations: Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Edinburgh, United Kingdom, Immunobiology Group, Medical Research Council (MRC) Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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  • William J Zacharias equal contributor,

    equal contributor Contributed equally to this work with: Charlie W Lees, William J Zacharias

    Affiliation: Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Mark Tremelling,

    Affiliation: Inflammatory Bowel Disease (IBD) Research Group, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom

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  • Colin L Noble,

    Affiliation: Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Edinburgh, United Kingdom

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  • Elaine R Nimmo,

    Affiliation: Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Edinburgh, United Kingdom

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  • Albert Tenesa,

    Affiliation: Colon Cancer Genetics Group, MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom

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  • Jennine Cornelius,

    Affiliation: Department of Pathology, Genentech, Inc, South San Francisco, California, United States of America

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  • Leif Torkvist,

    Affiliation: Department of Medical & Surgical Gastroenterology, Karolinska University Hospital, Stockholm, Sweden

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  • John Kao,

    Affiliation: Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Susan Farrington,

    Affiliation: Colon Cancer Genetics Group, MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom

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  • Hazel E Drummond,

    Affiliation: Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Edinburgh, United Kingdom

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  • Gwo-Tzer Ho,

    Affiliation: Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Edinburgh, United Kingdom

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  • Ian D. R Arnott,

    Affiliation: Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Edinburgh, United Kingdom

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  • Henry D Appelman,

    Affiliation: Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Lauri Diehl,

    Affiliation: Department of Pathology, Genentech, Inc, South San Francisco, California, United States of America

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  • Harry Campbell,

    Affiliation: Colon Cancer Genetics Group, MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom

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  • Malcolm G Dunlop,

    Affiliation: Colon Cancer Genetics Group, MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom

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  • Miles Parkes,

    Affiliation: Inflammatory Bowel Disease (IBD) Research Group, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom

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  • Sarah E. M Howie,

    Affiliation: Immunobiology Group, Medical Research Council (MRC) Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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  • Deborah L Gumucio mail,

    To whom correspondence should be addressed. E-mail: Charlie.lees@ed.ac.uk (CWL); dgumucio@umich.edu (DLG)

    Affiliation: Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

    These authors are joint senior authors on this work.

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  • Jack Satsangi

    Affiliation: Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Edinburgh, United Kingdom

    These authors are joint senior authors on this work.

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  • Published: December 09, 2008
  • DOI: 10.1371/journal.pmed.0050239

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