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Research Article

Exploring the Developmental Overnutrition Hypothesis Using Parental–Offspring Associations and FTO as an Instrumental Variable

  • Debbie A Lawlor mail,

    To whom correspondence should be addressed. E-mail: d.a.lawlor@bristol.ac.uk

    Affiliations: Medical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom, Department of Social Medicine, University of Bristol, Bristol, United Kingdom

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  • Nicholas J Timpson,

    Affiliations: Medical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Roger M Harbord,

    Affiliation: Department of Social Medicine, University of Bristol, Bristol, United Kingdom

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  • Sam Leary,

    Affiliation: Department of Oral and Dental Science, University of Bristol, Bristol, United Kingdom

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  • Andy Ness,

    Affiliation: Department of Oral and Dental Science, University of Bristol, Bristol, United Kingdom

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  • Mark I McCarthy,

    Affiliations: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom

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  • Timothy M Frayling,

    Affiliations: Genetics of Complex Traits, Institute of Biomedical and Clinical Sciences, Peninsula Medical School, Exeter, United Kingdom, Diabetes Genetics, Institute of Biomedical and Clinical Sciences, Peninsula Medical School, Exeter, United Kingdom

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  • Andrew T Hattersley,

    Affiliations: Genetics of Complex Traits, Institute of Biomedical and Clinical Sciences, Peninsula Medical School, Exeter, United Kingdom, Diabetes Genetics, Institute of Biomedical and Clinical Sciences, Peninsula Medical School, Exeter, United Kingdom

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  • George Davey Smith

    Affiliations: Medical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom, Department of Social Medicine, University of Bristol, Bristol, United Kingdom

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  • Published: March 11, 2008
  • DOI: 10.1371/journal.pmed.0050033

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