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Research Article

N348I in the Connection Domain of HIV-1 Reverse Transcriptase Confers Zidovudine and Nevirapine Resistance

  • Soo-Huey Yap,

    Affiliations: Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia, School of Applied Sciences and Engineering, Monash University, Churchill, Victoria, Australia

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  • Chih-Wei Sheen,

    Affiliation: Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Jonathan Fahey,

    Affiliations: Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia, Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Mark Zanin,

    Affiliation: Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia

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  • David Tyssen,

    Affiliation: Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia

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  • Viviane Dias Lima,

    Affiliation: British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada

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  • Brian Wynhoven,

    Affiliation: British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada

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  • Michael Kuiper,

    Affiliation: Victorian Partnership for Advanced Computing, Carlton South, Victoria, Australia

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  • Nicolas Sluis-Cremer,

    Affiliation: Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • P. Richard Harrigan,

    Affiliation: British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada

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  • Gilda Tachedjian mail

    To whom correspondence should be addressed. E-mail: gildat@burnet.edu.au

    Affiliations: Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia, Department of Microbiology, Monash University, Clayton, Victoria, Australia, Department of Medicine, Monash University, Melbourne, Victoria, Australia

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  • Published: December 01, 2007
  • DOI: 10.1371/journal.pmed.0040335

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