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Research Article

Expansion of Regulatory T Cells in Patients with Langerhans Cell Histiocytosis

  • Brigitte Senechal,

    Affiliations: INSERM, U838, Laboratory of Biology of the Mononuclear Phagocyte System, Necker Enfants Malades Institute, Paris, France, Université Paris Descartes Medical School, Paris, France

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  • Gaelle Elain,

    Affiliations: INSERM, U838, Laboratory of Biology of the Mononuclear Phagocyte System, Necker Enfants Malades Institute, Paris, France, Université Paris Descartes Medical School, Paris, France

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  • Eric Jeziorski,

    Affiliations: INSERM, U838, Laboratory of Biology of the Mononuclear Phagocyte System, Necker Enfants Malades Institute, Paris, France, Université Paris Descartes Medical School, Paris, France

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  • Virginie Grondin,

    Affiliations: INSERM, U838, Laboratory of Biology of the Mononuclear Phagocyte System, Necker Enfants Malades Institute, Paris, France, Université Paris Descartes Medical School, Paris, France

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  • Natacha Patey-Mariaud de Serre,

    Affiliations: INSERM, U838, Laboratory of Biology of the Mononuclear Phagocyte System, Necker Enfants Malades Institute, Paris, France, Université Paris Descartes Medical School, Paris, France, Department of Pathology, Hôpital Necker Enfants Malades and Assistance Publique–Hôpitaux de Paris, Paris, France

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  • Francis Jaubert,

    Affiliations: INSERM, U838, Laboratory of Biology of the Mononuclear Phagocyte System, Necker Enfants Malades Institute, Paris, France, Université Paris Descartes Medical School, Paris, France, Department of Pathology, Hôpital Necker Enfants Malades and Assistance Publique–Hôpitaux de Paris, Paris, France

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  • Kheira Beldjord,

    Affiliations: Université Paris Descartes Medical School, Paris, France, Department of Laboratory Medicine, Hôpital Necker Enfants Malades and Assistance Publique–Hôpitaux de Paris, Paris, France

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  • Arielle Lellouch,

    Affiliations: Université Paris Descartes Medical School, Paris, France, Department of Pathology, Hôpital Necker Enfants Malades and Assistance Publique–Hôpitaux de Paris, Paris, France

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  • Christophe Glorion,

    Affiliations: Université Paris Descartes Medical School, Paris, France, Department of Orthopedic Surgery, Hôpital Necker Enfants Malades and Assistance Publique–Hôpitaux de Paris, Paris, France

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  • Michel Zerah,

    Affiliations: Université Paris Descartes Medical School, Paris, France, Department of Neurosurgery, Hôpital Necker Enfants Malades and Assistance Publique–Hôpitaux de Paris, Paris, France

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  • Pierre Mary,

    Affiliation: Department of Orthopedic Surgery, Hôpital d'Enfants Armand Trousseau and Assistance Publique–Hôpitaux de Paris, Paris, France

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  • Mohammed Barkaoui,

    Affiliation: Delegation a la Recherche Clinique, Centre Hospitalier Universitaire de Nantes, Nantes, France

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  • Jean Francois Emile,

    Affiliation: Laboratory of Pathology, Hôpital Ambroise-Paré and Assistance Publique–Hôpitaux de Paris Boulogne Billancourt, France

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  • Liliane Boccon-Gibod,

    Affiliation: Department of Pathology, Assistance Publique–Hôpitaux de Paris, Hôpital d'Enfants Armand Trousseau, Paris, France

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  • Patrice Josset,

    Affiliation: Department of Pathology, Assistance Publique–Hôpitaux de Paris, Hôpital d'Enfants Armand Trousseau, Paris, France

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  • Marianne Debré,

    Affiliation: Immunology and Hematology Unit, Department of Pediatrics, Assistance Publique–Hôpitaux de Paris and Necker Enfants Malades Hospital, Paris, France

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  • Alain Fischer,

    Affiliations: Université Paris Descartes Medical School, Paris, France, Immunology and Hematology Unit, Department of Pediatrics, Assistance Publique–Hôpitaux de Paris and Necker Enfants Malades Hospital, Paris, France

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  • Jean Donadieu,

    Affiliation: Department of Hematology, Assistance Publique–Hôpitaux de Paris and Hôpital d'Enfants Armand Trousseau, Paris, France

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  • Frederic Geissmann mail

    To whom correspondence should be addressed. E-mail: geissman@necker.fr

    Affiliations: INSERM, U838, Laboratory of Biology of the Mononuclear Phagocyte System, Necker Enfants Malades Institute, Paris, France, Université Paris Descartes Medical School, Paris, France, Department of Pathology, Hôpital Necker Enfants Malades and Assistance Publique–Hôpitaux de Paris, Paris, France

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  • Published: August 14, 2007
  • DOI: 10.1371/journal.pmed.0040253

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