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Research Article

A Novel Substrate-Based HIV-1 Protease Inhibitor Drug Resistance Mechanism

  • Monique Nijhuis,

    Affiliation: Eijkman Winkler Center, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands

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  • Noortje M van Maarseveen,

    Affiliation: Eijkman Winkler Center, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands

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  • Stephane Lastere,

    Affiliation: APHP-Hopital Bichat, Laboratoire Virologie, Paris, France

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  • Pauline Schipper,

    Affiliation: Eijkman Winkler Center, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands

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  • Eoin Coakley,

    Affiliation: Monogram Biosciences, San Francisco, California, United States of America

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  • Bärbel Glass,

    Affiliation: Department of Virology, University of Heidelberg, Heidelberg, Germany

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  • Mirka Rovenska,

    Affiliation: Institute of Organic Chemistry and Biochemistry, Academy of Science of the Czech Republic, Prague, Czech Republic

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  • Dorien de Jong,

    Affiliation: Eijkman Winkler Center, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands

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  • Colombe Chappey,

    Affiliation: Monogram Biosciences, San Francisco, California, United States of America

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  • Irma W Goedegebuure,

    Affiliation: Eijkman Winkler Center, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands

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  • Gabrielle Heilek-Snyder,

    Affiliation: Roche Bioscience, Palo Alto, California, United States of America

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  • Dominic Dulude,

    Affiliation: Department of Biochemistry, Université de Montreal, Montreal, Canada

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  • Nick Cammack,

    Affiliation: Roche Bioscience, Palo Alto, California, United States of America

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  • Lea Brakier-Gingras,

    Affiliation: Department of Biochemistry, Université de Montreal, Montreal, Canada

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  • Jan Konvalinka,

    Affiliation: Institute of Organic Chemistry and Biochemistry, Academy of Science of the Czech Republic, Prague, Czech Republic

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  • Neil Parkin,

    Affiliation: Monogram Biosciences, San Francisco, California, United States of America

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  • Hans-Georg Kräusslich,

    Affiliation: Department of Virology, University of Heidelberg, Heidelberg, Germany

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  • Francoise Brun-Vezinet,

    Affiliation: APHP-Hopital Bichat, Laboratoire Virologie, Paris, France

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  • Charles A. B Boucher mail

    To whom correspondence should be addressed. E-mail: c.boucher@umcutrecht.nl

    Affiliation: Eijkman Winkler Center, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands

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  • Published: January 16, 2007
  • DOI: 10.1371/journal.pmed.0040036

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