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Research Article

Lentiviral Gene Transfer of Rpe65 Rescues Survival and Function of Cones in a Mouse Model of Leber Congenital Amaurosis

  • Alexis-Pierre Bemelmans equal contributor,

    equal contributor Contributed equally to this work with: Alexis-Pierre Bemelmans, Corinne Kostic

    Affiliation: Unit of Gene Therapy and Stem Cell Biology, Jules Gonin Eye Hospital, Lausanne, Switzerland

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  • Corinne Kostic equal contributor,

    equal contributor Contributed equally to this work with: Alexis-Pierre Bemelmans, Corinne Kostic

    Affiliation: Unit of Gene Therapy and Stem Cell Biology, Jules Gonin Eye Hospital, Lausanne, Switzerland

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  • Sylvain V Crippa,

    Affiliation: Unit of Gene Therapy and Stem Cell Biology, Jules Gonin Eye Hospital, Lausanne, Switzerland

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  • William W Hauswirth,

    Affiliation: Department of Ophthalmology, University of Florida, Gainesville, Florida, United States of America

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  • Janis Lem,

    Affiliation: Department of Ophthalmology, Program in Genetics and Tufts Center for Vision Research, Tufts University School of Medicine, Boston, Massachusetts, United States of America

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  • Francis L Munier,

    Affiliation: Unit of Clinical Oculogenetics, Jules Gonin Eye Hospital, Lausanne, Switzerland

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  • Mathias W Seeliger,

    Affiliation: Retinal Electrodiagnostics Research Group, Department of Ophthalmology II, Eberhard-Karls University, Tübingen, Germany

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  • Andreas Wenzel,

    Affiliation: Laboratory of Retinal Cell Biology, University Hospital, Zürich, Switzerland

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  • Yvan Arsenijevic mail

    To whom correspondence should be addressed. E-mail: yvan.arsenijevic@ophtal.vd.ch

    Affiliation: Unit of Gene Therapy and Stem Cell Biology, Jules Gonin Eye Hospital, Lausanne, Switzerland

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  • Published: October 10, 2006
  • DOI: 10.1371/journal.pmed.0030347

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