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Research Article

Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape Mutants

  • Jan ter Meulen equal contributor mail,

    equal contributor Contributed equally to this work with: Jan ter Meulen, Edward N van den Brink

    To whom correspondence should be addressed. E-mail: j.termeulen@crucell.com

    Affiliation: Crucell Holland B.V., Leiden, Netherlands

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  • Edward N van den Brink equal contributor,

    equal contributor Contributed equally to this work with: Jan ter Meulen, Edward N van den Brink

    Affiliation: Crucell Holland B.V., Leiden, Netherlands

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  • Leo L. M Poon,

    Affiliation: Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region of the People's Republic of China

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  • Wilfred E Marissen,

    Affiliation: Crucell Holland B.V., Leiden, Netherlands

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  • Cynthia S. W Leung,

    Affiliation: Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region of the People's Republic of China

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  • Freek Cox,

    Affiliation: Crucell Holland B.V., Leiden, Netherlands

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  • Chung Y Cheung,

    Affiliation: Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region of the People's Republic of China

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  • Arjen Q Bakker,

    Affiliation: Crucell Holland B.V., Leiden, Netherlands

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  • Johannes A Bogaards,

    Affiliation: Crucell Holland B.V., Leiden, Netherlands

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  • Els van Deventer,

    Affiliation: Crucell Holland B.V., Leiden, Netherlands

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  • Wolfgang Preiser,

    Affiliation: Institute for Medical Virology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany

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  • Hans Wilhelm Doerr,

    Affiliation: Institute for Medical Virology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany

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  • Vincent T Chow,

    Affiliation: Department of Microbiology, Yong Loo Lin School Faculty of Medicine, National University of Singapore, Singapore

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  • John de Kruif,

    Affiliation: Crucell Holland B.V., Leiden, Netherlands

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  • Joseph S. M Peiris,

    Affiliation: Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region of the People's Republic of China

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  • Jaap Goudsmit

    Affiliation: Crucell Holland B.V., Leiden, Netherlands

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  • Published: July 04, 2006
  • DOI: 10.1371/journal.pmed.0030237

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