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Research Article

Large-Scale Evidence for the Effect of the COLIA1 Sp1 Polymorphism on Osteoporosis Outcomes: The GENOMOS Study

  • Stuart H Ralston,

    Affiliations: Rheumatic Diseases Unit, University of Edinburgh, Western General Hospital Edinburgh, Edinburgh, United Kingdom, Department of Medicine and Therapeutics, University of Aberdeen Medical School, Aberdeen, United Kingdom

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  • André G Uitterlinden,

    Affiliation: Department of Internal Medicine, Erasmus MC, Rotterdam, Netherlands

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  • Maria Luisa Brandi,

    Affiliation: Department of Internal Medicine, University of Florence, Florence, Italy

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  • Susana Balcells,

    Affiliation: Department of Genetics, University of Barcelona, Barcelona, Spain

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  • Bente L Langdahl,

    Affiliation: Department of Endocrinology, Aarhus Sygehus, Aarhus, Denmark

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  • Paul Lips,

    Affiliation: Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, Netherlands

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  • Roman Lorenc,

    Affiliation: Department of Biochemistry and Experimental Medicine, The Children's Memorial Health Institute, Warsaw, Poland

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  • Barbara Obermayer-Pietsch,

    Affiliation: Department of Endocrinology and Nuclear Medicine, University of Graz, Graz, Austria

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  • Serena Scollen,

    Affiliation: Strangeways Research Laboratory, Cambridge University, Cambridge, United Kingdom

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  • Mariona Bustamante,

    Affiliation: Department of Genetics, University of Barcelona, Barcelona, Spain

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  • Lise Bjerre Husted,

    Affiliation: Department of Endocrinology, Aarhus Sygehus, Aarhus, Denmark

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  • Alisoun H Carey,

    Affiliation: Oxagen Limited, Abingdon, United Kingdom

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  • Adolfo Diez-Perez,

    Affiliation: Hospital del Mar-IMIM, Universitat Autònoma de Barcelona, Barcelona, Spain

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  • Alison M Dunning,

    Affiliation: Strangeways Research Laboratory, Cambridge University, Cambridge, United Kingdom

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  • Alberto Falchetti,

    Affiliation: Department of Internal Medicine, University of Florence, Florence, Italy

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  • Elzbieta Karczmarewicz,

    Affiliation: Department of Biochemistry and Experimental Medicine, The Children's Memorial Health Institute, Warsaw, Poland

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  • Marcin Kruk,

    Affiliation: Department of Biochemistry and Experimental Medicine, The Children's Memorial Health Institute, Warsaw, Poland

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  • Johannes P. T. M. van Leeuwen,

    Affiliation: Department of Internal Medicine, Erasmus MC, Rotterdam, Netherlands

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  • Joyce B. J. van Meurs,

    Affiliation: Department of Internal Medicine, Erasmus MC, Rotterdam, Netherlands

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  • Jon Mangion,

    Affiliation: Oxagen Limited, Abingdon, United Kingdom

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  • Fiona E. A McGuigan,

    Affiliation: Department of Medicine and Therapeutics, University of Aberdeen Medical School, Aberdeen, United Kingdom

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  • Leonardo Mellibovsky,

    Affiliation: Hospital del Mar-IMIM, Universitat Autònoma de Barcelona, Barcelona, Spain

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  • Francesca del Monte,

    Affiliation: Department of Internal Medicine, University of Florence, Florence, Italy

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  • Huibert A. P Pols,

    Affiliation: Department of Internal Medicine, Erasmus MC, Rotterdam, Netherlands

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  • Jonathan Reeve,

    Affiliation: Strangeways Research Laboratory, Cambridge University, Cambridge, United Kingdom

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  • David M Reid,

    Affiliation: Department of Medicine and Therapeutics, University of Aberdeen Medical School, Aberdeen, United Kingdom

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  • Wilfried Renner,

    Affiliation: Department of Endocrinology and Nuclear Medicine, University of Graz, Graz, Austria

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  • Fernando Rivadeneira,

    Affiliation: Department of Internal Medicine, Erasmus MC, Rotterdam, Netherlands

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  • Natasja M. van Schoor,

    Affiliation: Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, Netherlands

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  • Rachael E Sherlock,

    Affiliation: Oxagen Limited, Abingdon, United Kingdom

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  • John P. A Ioannidis,

    Affiliation: Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine and Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina, Greece

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  • for the GENOMOS investigators
  • Published: February 21, 2006
  • DOI: 10.1371/journal.pmed.0030090

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Linked Articles

Correction: Large-Scale Evidence for the Effect of the COLIA1 Sp1 Polymorphism on Osteoporosis Outcomes: The GENOMOS Study

Stuart H Ralston, André G Uitterlinden, Maria Luisa Brandi, Susana Balcells, Bente L Langdahl, Paul Lips, Roman Lorenc, Barbara Obermayer-Pietsch, Serena Scollen, Mariona Bustamante, Lise Bjerre Husted, ...
Correction | published 30 May 2006 | PLOS Medicine
doi:10.1371/journal.pmed.0030223

GENOMOS Study Finds Weak Links between COL1A1 Polymorphism, BMD, and Fracture Risk

Synopsis | published 21 Feb 2006 | PLOS Medicine
doi:10.1371/journal.pmed.0030152