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Research Article

Gene Expression Programs in Response to Hypoxia: Cell Type Specificity and Prognostic Significance in Human Cancers

  • Jen-Tsan Chi equal contributor,

    equal contributor Contributed equally to this work with: Jen-Tsan Chi, Zhen Wang

    Affiliations: Department of Biochemistry, Stanford University School of Medicine, Palo Alto, California, United States of America, The Institute of Genome Sciences and Policy, Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, United States of America

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  • Zhen Wang equal contributor,

    equal contributor Contributed equally to this work with: Jen-Tsan Chi, Zhen Wang

    Affiliation: Department of Surgery, Stanford University School of Medicine, Palo Alto, California, United States of America

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  • Dimitry S. A Nuyten,

    Affiliation: Diagnostic Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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  • Edwin H Rodriguez,

    Affiliation: Department of Biochemistry, Stanford University School of Medicine, Palo Alto, California, United States of America

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  • Marci E Schaner,

    Affiliation: Department of Biochemistry, Stanford University School of Medicine, Palo Alto, California, United States of America

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  • Ali Salim,

    Affiliations: Department of Surgery, Stanford University School of Medicine, Palo Alto, California, United States of America, Department of Radiation Oncology, Stanford University School of Medicine, Palo Alto, California, United States of America

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  • Yun Wang,

    Affiliations: Department of Gynecologic Oncology, The Norwegian Radium Hospital, Oslo, Norway, Department of Genetics, The Norwegian Radium Hospital, Oslo, Norway

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  • Gunnar B Kristensen,

    Affiliation: Department of Gynecologic Oncology, The Norwegian Radium Hospital, Oslo, Norway

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  • Åslaug Helland,

    Affiliations: Department of Gynecologic Oncology, The Norwegian Radium Hospital, Oslo, Norway, Department of Genetics, The Norwegian Radium Hospital, Oslo, Norway

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  • Anne-Lise Børresen-Dale,

    Affiliation: Department of Genetics, The Norwegian Radium Hospital, Oslo, Norway

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  • Amato Giaccia,

    Affiliation: Department of Radiation Oncology, Stanford University School of Medicine, Palo Alto, California, United States of America

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  • Michael T Longaker,

    Affiliation: Department of Surgery, Stanford University School of Medicine, Palo Alto, California, United States of America

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  • Trevor Hastie,

    Affiliation: Health Research and Policy, Stanford University School of Medicine, Palo Alto, California, United States of America

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  • George P Yang,

    Affiliations: Department of Surgery, Stanford University School of Medicine, Palo Alto, California, United States of America, Palo Alto VA Health Care System, Palo Alto, Stanford University School of Medicine, Palo Alto, California, United States of America

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  • Marc J van de Vijver,

    Affiliation: Diagnostic Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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  • Patrick O Brown mail

    To whom correspondence should be addressed. E-mail: pbrown@pmgm2.stanford.edu

    Affiliations: Department of Biochemistry, Stanford University School of Medicine, Palo Alto, California, United States of America, Howard Hughes Medical Institute, Stanford University School of Medicine, Palo Alto, California, United States of America

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  • Published: January 24, 2006
  • DOI: 10.1371/journal.pmed.0030047

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Linked Articles

Hypoxia Responses: How Different Cells and Tumors React to Oxygen Shortage

Synopsis | published 24 Jan 2006 | PLOS Medicine
doi:10.1371/journal.pmed.0030105