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Research Article

A C1173T Dimorphism in the VKORC1 Gene Determines Coumarin Sensitivity and Bleeding Risk

  • Pieter H Reitsma mail,

    To whom correspondence should be addressed. E-mail: p.h.reitsma@amc.uva.nl

    Affiliation: Laboratory for Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Jeroen F. van der Heijden,

    Affiliation: Laboratory for Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Angelique P Groot,

    Affiliation: Laboratory for Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Frits R Rosendaal,

    Affiliation: Departments of Clinical Epidemiology and Hematology, Leiden University Medical Center, Leiden, The Netherlands

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  • Harry R Büller

    Affiliation: Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Published: October 11, 2005
  • DOI: 10.1371/journal.pmed.0020312

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Linked Articles

Pharmacogenetics in the Management of Coumarin Anticoagulant Therapy: The Way Forward or an Expensive Diversion?

Mike Greaves
Perspective | published 25 Oct 2005 | PLOS Medicine
doi:10.1371/journal.pmed.0020342

Understanding Bleeding Risk after Anticoagulation

Synopsis | published 11 Oct 2005 | PLOS Medicine
doi:10.1371/journal.pmed.0020352