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Research Article

Fialuridine Induces Acute Liver Failure in Chimeric TK-NOG Mice: A Model for Detecting Hepatic Drug Toxicity Prior to Human Testing

  • Dan Xu,

    Affiliation: Department of Anesthesia, Stanford University School of Medicine, Stanford, California, United States of America

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  • Toshi Nishimura,

    Affiliations: Department of Anesthesia, Stanford University School of Medicine, Stanford, California, United States of America, Central Institute for Experimental Animals, Kawasaki, Japan, Center for the Advancement of Health and Biosciences, Sunnyvale, California, United States of America

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  • Sachiko Nishimura,

    Affiliation: Center for the Advancement of Health and Biosciences, Sunnyvale, California, United States of America

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  • Haili Zhang,

    Affiliation: Department of Anesthesia, Stanford University School of Medicine, Stanford, California, United States of America

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  • Ming Zheng,

    Affiliation: Department of Anesthesia, Stanford University School of Medicine, Stanford, California, United States of America

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  • Ying-Ying Guo,

    Affiliation: Department of Drug Disposition, Eli Lilly and Company, Indianapolis, Indiana, United States of America

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  • Marylin Masek,

    Affiliations: Department of Medicine, Stanford University School of Medicine, Stanford California, United States of America, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford California, United States of America, Department of Pathology, Stanford University School of Medicine, Stanford California, United States of America

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  • Sara A. Michie,

    Affiliations: Department of Medicine, Stanford University School of Medicine, Stanford California, United States of America, Department of Pathology, Stanford University School of Medicine, Stanford California, United States of America

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  • Jeffrey Glenn mail,

    jeffrey.glenn@stanford.edu (JG); gpeltz@stanford.edu (GP)

    Affiliations: Department of Medicine, Stanford University School of Medicine, Stanford California, United States of America, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford California, United States of America

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  • Gary Peltz mail

    jeffrey.glenn@stanford.edu (JG); gpeltz@stanford.edu (GP)

    Affiliation: Department of Anesthesia, Stanford University School of Medicine, Stanford, California, United States of America

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  • Published: April 15, 2014
  • DOI: 10.1371/journal.pmed.1001628

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