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Research Article

Multidrug Resistant Pulmonary Tuberculosis Treatment Regimens and Patient Outcomes: An Individual Patient Data Meta-analysis of 9,153 Patients

  • Shama D. Ahuja,

    Affiliation: Bureau of Tuberculosis, New York, New York, United States of America

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  • David Ashkin,

    Affiliation: A.G. Holley Hospital, Lantana, Florida, United States of America

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  • Monika Avendano,

    Affiliation: University of Toronto, Toronto, Canada

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  • Rita Banerjee,

    Affiliation: Mayo Clinic, Rochester, Minnesota, United States of America

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  • Melissa Bauer,

    Affiliation: Montreal Chest Institute, McGill University, Montreal, Canada

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  • Jamie N. Bayona,

    Affiliation: The Dartmouth Center for Health Care Delivery Science, Hanover, New Hampshire, United States of America

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  • Mercedes C. Becerra,

    Affiliations: Harvard Medical School, Boston, Massachusetts, United States of America, Partners in Health, Boston, Massachusetts, United States of America

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  • Andrea Benedetti,

    Affiliation: Montreal Chest Institute, McGill University, Montreal, Canada

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  • Marcos Burgos,

    Affiliation: University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America

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  • Rosella Centis,

    Affiliation: WHO Collaborating Centre for TB and Lung Diseases, Care and Research Institute, Fondazione S. Maugeri, Tradate, Italy

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  • Eward D. Chan,

    Affiliation: Denver Veterans Affair Medical Center, Denver, Colorado, United States of America

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  • Chen-Yuan Chiang,

    Affiliation: Wan Fang Hospital, School of Medicine-Taipei Medical University, Taiwan

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  • Helen Cox,

    Affiliation: Médecins Sans Frontières, Capetown, South Africa

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  • Lia D'Ambrosio,

    Affiliation: WHO Collaborating Centre for TB and Lung Diseases, Care and Research Institute, Fondazione S. Maugeri, Tradate, Italy

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  • Kathy DeRiemer,

    Affiliation: UC Davis School of Medicine, Davis, California, United States of America

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  • Nguyen Huy Dung,

    Affiliation: National TB Control Program, Hanoi, Vietnam

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  • Donald Enarson,

    Affiliation: International Union against Tuberculosis and Lung Disease, Paris, France

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  • Dennis Falzon,

    Affiliation: World Health Organization, Geneva, Switzerland

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  • Katherine Flanagan,

    Affiliation: MRC Laboratories, Banjul, The Gambia

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  • Jennifer Flood,

    Affiliation: California Department of Public Health, Sacramento, California, United States of America

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  • Maria L. Garcia-Garcia,

    Affiliation: Instituto Nacional de Salud Pública, Mexico, Mexico

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  • Neel Gandhi,

    Affiliation: Albert Einstein College of Medicine, Bronx, New York, United States of America

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  • Reuben M. Granich,

    Affiliation: World Health Organization, Geneva, Switzerland

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  • Maria G. Hollm-Delgado,

    Affiliation: Montreal Chest Institute, McGill University, Montreal, Canada

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  • Timothy H. Holtz,

    Affiliation: Thailand MOPH & US CDC Collaboration, Bangkok, Thailand

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  • Michael D. Iseman,

    Affiliation: National Jewish Health, Denver, Colorado, United States of America

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  • Leah G. Jarlsberg,

    Affiliation: University of California, San Francisco, San Francisco, United States of America

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  • Salmaan Keshavjee,

    Affiliation: Harvard Medical School, Boston, Massachusetts, United States of America

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  • Hye-Ryoun Kim,

    Affiliation: Korea Cancer Center Hospital, Seoul, Korea

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  • Won-Jung Koh,

    Affiliation: Samsung Medical Center, Seoul, Korea

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  • Joey Lancaster,

    Affiliation: South African Medical Research Council, Pretoria, South Africa

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  • Christophe Lange,

    Affiliation: Medical Clinic, Tuberculosis Center Borstel, Borstel, Germany

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  • Wiel C. M. de Lange,

    Affiliation: University Medical Center Groningen, Groningen, The Netherlands

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  • Vaira Leimane,

    Affiliation: Clinic of Tuberculosis and Lung Diseases, Riga, Latvia

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  • Chi Chiu Leung,

    Affiliation: Tuberculosis and Chest Services, Hong Kong

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  • Jiehui Li,

    Affiliation: New York City Health and Mental Hygiene, New York, New York, United States of America

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  • Dick Menzies mail,

    Dick.Menzies@McGill.ca

    Affiliation: Montreal Chest Institute, McGill University, Montreal, Canada

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  • Giovanni B. Migliori,

    Affiliation: WHO Collaborating Centre for TB and Lung Diseases, Care and Research Institute, Fondazione S. Maugeri, Tradate, Italy

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  • Sergey P. Mishustin,

    Affiliation: Tomsk Oblast Tuberculosis Dispensary, Tomsk, Russia

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  • Carole D. Mitnick,

    Affiliation: Harvard Medical School, Boston, Massachusetts, United States of America

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  • Masa Narita,

    Affiliation: University of Washington, Seattle, Washington, United States of America

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  • Philly O'Riordan,

    Affiliation: City Road Medical Centre, London, United Kingdom

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  • Madhukar Pai,

    Affiliation: Montreal Chest Institute, McGill University, Montreal, Canada

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  • Domingo Palmero,

    Affiliation: Hospital F.J. Muñiz, Buenos Aires, Argentina

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  • Seung-kyu Park,

    Affiliation: TB Center, Seoul, Korea

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  • Geoffrey Pasvol,

    Affiliation: Imperial College London, London, United Kingdom

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  • Jose Peña,

    Affiliation: Universidad Autonoma Madrid, Madrid, Spain

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  • Carlos Pérez-Guzmán,

    Affiliation: Instituto de Salud del Estado de Aguascalientes, Mexico, Mexico

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  • Maria I. D. Quelapio,

    Affiliation: Tropical Disease Foundation, Makati City, Philippines

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  • Alfredo Ponce-de-Leon,

    Affiliation: Instituto Nacional de Ciencias Médicas y de Nutrición “Salvador Zubirán”, Mexico, Mexico

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  • Vija Riekstina,

    Affiliation: Clinic of Tuberculosis and Lung Diseases, Riga, Latvia

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  • Jerome Robert,

    Affiliation: Bactériologie-Hygiène – UPMC, Paris, France

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  • Sarah Royce,

    Affiliation: University of California, San Francisco, San Francisco, United States of America

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  • H. Simon Schaaf,

    Affiliation: Stellenbosch University, Stellenbosch, South Africa

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  • Kwonjune J. Seung,

    Affiliation: Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • Lena Shah,

    Affiliation: Montreal Chest Institute, McGill University, Montreal, Canada

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  • Tae Sun Shim,

    Affiliation: University of Ulsan College of Medicine, Seoul, Korea

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  • Sonya S. Shin,

    Affiliation: Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • Yuji Shiraishi,

    Affiliation: Fukujuji Hospital, Tokyo, Japan

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  • José Sifuentes-Osornio,

    Affiliation: Instituto Nacional de Ciencias Médicas y de Nutrición “Salvador Zubirán”, Mexico, Mexico

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  • Giovanni Sotgiu,

    Affiliation: University of Sassari, Sassari, Italy

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  • Matthew J. Strand,

    Affiliation: National Jewish Health, Denver, Colorado, United States of America

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  • Payam Tabarsi,

    Affiliation: Shaheed Beheshti Medical University, Tehran, Iran

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  • Thelma E. Tupasi,

    Affiliation: Tropical Disease Foundation, Makati City, Philippines

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  • Robert van Altena,

    Affiliation: University Medical Center Groningen, Groningen, The Netherlands

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  • Martie Van der Walt,

    Affiliation: South African Medical Research Council, Pretoria, South Africa

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  • Tjip S. Van der Werf,

    Affiliation: University Medical Center Groningen, Groningen, The Netherlands

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  • Mario H. Vargas,

    Affiliation: Instituto Nacional de Enfermedades Respiratorias, Mexico, Mexico

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  • Pirett Viiklepp,

    Affiliation: National Institute for Health Development, Tallinn, Estonia

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  • Janice Westenhouse,

    Affiliation: Center for Infectious Diseases-California Department of Public Health, Sacramento, California, United States of America

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  • Wing Wai Yew,

    Affiliation: Grantham Hospital, Hong Kong

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  • Jae-Joon Yim, on behalf of the Collaborative Group for Meta-Analysis of Individual Patient Data in MDR-TB,

    Affiliation: Seoul National University College of Medicine, Seoul, Korea

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  • Shama D. Ahuja

    All members of the Collaborative Group for Meta-Analysis of Individual Patient Data in MDR-TB are the authors and are listed in the manuscript byline.

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  • Published: August 28, 2012
  • DOI: 10.1371/journal.pmed.1001300

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