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Research Article

Diagnosing Severe Falciparum Malaria in Parasitaemic African Children: A Prospective Evaluation of Plasma PfHRP2 Measurement

  • Ilse C. E. Hendriksen,

    Affiliations: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom

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  • Juliet Mwanga-Amumpaire,

    Affiliation: Mbarara University of Science and Technology and Epicentre Research Base, Mbarara, Uganda

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  • Lorenz von Seidlein,

    Affiliation: Menzies School of Health Research, Casuarina, NT, Australia

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  • George Mtove,

    Affiliation: National Institute for Medical Research, Amani Centre, Tanga, Tanzania

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  • Lisa J. White,

    Affiliations: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom

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  • Rasaq Olaosebikan,

    Affiliation: Medical Research Council Laboratories, Banjul, The Gambia

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  • Sue J. Lee,

    Affiliations: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom

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  • Antoinette K. Tshefu,

    Affiliation: Kinshasa School of Public Health, Kingasani Research Centre, Kinshasa, Democratic Republic of the Congo

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  • Charles Woodrow,

    Affiliations: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom

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  • Ben Amos,

    Affiliation: Teule Hospital, Muheza, Tanzania

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  • Corine Karema,

    Affiliation: Malaria Control Program, Ministry of Health, Kigali, Rwanda

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  • Somporn Saiwaew,

    Affiliation: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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  • Kathryn Maitland,

    Affiliation: Kenya Medical Research Institute (KEMRI)–Wellcome Trust Research Programme, Kilifi, Kenya

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  • Ermelinda Gomes,

    Affiliation: Hospital Central da Beira, Beira, Mozambique

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  • Wirichada Pan-Ngum,

    Affiliation: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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  • Samwel Gesase,

    Affiliation: National Institute for Medical Research, Tanga Medical Research Centre, Tanga, Tanzania

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  • Kamolrat Silamut,

    Affiliation: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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  • Hugh Reyburn,

    Affiliation: London School of Tropical Medicine & Hygiene, London, United Kingdom

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  • Sarah Joseph,

    Affiliation: Medical Research Council, London, United Kingdom

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  • Kesinee Chotivanich,

    Affiliation: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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  • Caterina I. Fanello,

    Affiliations: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom

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  • Nicholas P. J. Day,

    Affiliations: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom

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  • Nicholas J. White,

    Affiliations: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom

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  • Arjen M. Dondorp mail

    arjen@tropmedres.ac

    Affiliations: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom

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  • Published: August 21, 2012
  • DOI: 10.1371/journal.pmed.1001297

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