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Research Article

Integrative Genomic Analyses Identify BRF2 as a Novel Lineage-Specific Oncogene in Lung Squamous Cell Carcinoma

  • William W. Lockwood mail,

    wlockwood@bccrc.ca

    Affiliation: Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

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  • Raj Chari,

    Affiliation: Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

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  • Bradley P. Coe,

    Affiliation: Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

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  • Kelsie L. Thu,

    Affiliation: Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

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  • Cathie Garnis,

    Affiliation: Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

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  • Chad A. Malloff,

    Affiliation: Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

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  • Jennifer Campbell,

    Affiliation: Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

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  • Ariane C. Williams,

    Affiliation: Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

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  • Dorothy Hwang,

    Affiliation: Department of Cancer Imaging, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

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  • Chang-Qi Zhu,

    Affiliation: Department of Pathology, Division of Applied Molecular Oncology, University Health Network - Princess Margaret Hospital and Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada

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  • Timon P. H. Buys,

    Affiliation: Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

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  • John Yee,

    Affiliation: Department of Surgery, Vancouver General Hospital, Vancouver, British Columbia

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  • John C. English,

    Affiliation: Department of Pathology, Vancouver General Hospital, Vancouver, British Columbia

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  • Calum MacAulay,

    Affiliation: Department of Cancer Imaging, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

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  • Ming-Sound Tsao,

    Affiliation: Department of Pathology, Division of Applied Molecular Oncology, University Health Network - Princess Margaret Hospital and Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada

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  • Adi F. Gazdar,

    Affiliation: Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas

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  • John D. Minna,

    Affiliation: Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas

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  • Stephen Lam,

    Affiliation: Department of Cancer Imaging, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

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  • Wan L. Lam

    Affiliation: Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

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  • Published: July 27, 2010
  • DOI: 10.1371/journal.pmed.1000315

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