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Research Article

Emergence of Azole Resistance in Aspergillus fumigatus and Spread of a Single Resistance Mechanism

  • Eveline Snelders,

    Affiliations: Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Nijmegen Institute for Infectious Diseases, Inflammation and Immunity, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Henrich A. L van der Lee,

    Affiliations: Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Nijmegen Institute for Infectious Diseases, Inflammation and Immunity, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Judith Kuijpers,

    Affiliations: Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Nijmegen Institute for Infectious Diseases, Inflammation and Immunity, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Anthonius J. M. M Rijs,

    Affiliations: Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Nijmegen Institute for Infectious Diseases, Inflammation and Immunity, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • János Varga,

    Affiliations: Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Utrecht, The Netherlands, Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Hungary

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  • Robert A Samson,

    Affiliation: Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Utrecht, The Netherlands

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  • Emilia Mellado,

    Affiliation: Servicio de Micologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain

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  • A. Rogier T Donders,

    Affiliation: Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Willem J. G Melchers,

    Affiliations: Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Nijmegen Institute for Infectious Diseases, Inflammation and Immunity, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Paul E Verweij mail

    To whom correspondence should be addressed. E-mail: p.verweij@mmb.umcn.nl

    Affiliations: Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Nijmegen Institute for Infectious Diseases, Inflammation and Immunity, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Published: November 11, 2008
  • DOI: 10.1371/journal.pmed.0050219

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