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Research Article

Inflammation, Insulin Resistance, and Diabetes—Mendelian Randomization Using CRP Haplotypes Points Upstream

  • Eric J Brunner mail,

    To whom correspondence should be addressed. E-mail: e.brunner@ucl.ac.uk

    Affiliation: Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, United Kingdom

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  • Mika Kivimäki,

    Affiliation: Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, United Kingdom

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  • Daniel R Witte,

    Affiliation: Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, United Kingdom

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  • Debbie A Lawlor,

    Affiliation: Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom

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  • George Davey Smith,

    Affiliation: Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom

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  • Jackie A Cooper,

    Affiliation: Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College London Medical School, London, United Kingdom

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  • Michelle Miller,

    Affiliation: Clinical Sciences Research Institute, Warwick Medical School, Coventry, United Kingdom

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  • Gordon D. O Lowe,

    Affiliation: Division of Cardiovascular and Medical Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom

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  • Ann Rumley,

    Affiliation: Division of Cardiovascular and Medical Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom

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  • Juan P Casas,

    Affiliation: Non-communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • Tina Shah,

    Affiliation: University College London Centre for Clinical Pharmacology, Division of Medicine, London, United Kingdom

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  • Steve E Humphries,

    Affiliation: Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College London Medical School, London, United Kingdom

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  • Aroon D Hingorani,

    Affiliation: Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, United Kingdom

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  • Michael G Marmot,

    Affiliation: Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, United Kingdom

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  • Nicholas J Timpson,

    Affiliation: Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom

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  • Meena Kumari

    Affiliation: Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, United Kingdom

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  • Published: August 12, 2008
  • DOI: 10.1371/journal.pmed.0050155

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