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Research Article

Gene-Environment Interaction in the Onset of Eczema in Infancy: Filaggrin Loss-of-Function Mutations Enhanced by Neonatal Cat Exposure

  • Hans Bisgaard mail,

    To whom correspondence should be addressed. E-mail: bisgaard@copsac.com

    Affiliation: Copenhagen Prospective Studies on Asthma in Childhood, Danish Paediatric Asthma Centre, Copenhagen, University Hospital Gentofte, Copenhagen, Denmark

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  • Angela Simpson,

    Affiliation: School of Translational Medicine, University of Manchester, University Hospital of South Manchester National Health Service Foundation Trust, Manchester, United Kingdom

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  • Colin N.A Palmer,

    Affiliation: Population Pharmacogenetics Group, Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom

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  • Klaus Bønnelykke,

    Affiliation: Copenhagen Prospective Studies on Asthma in Childhood, Danish Paediatric Asthma Centre, Copenhagen, University Hospital Gentofte, Copenhagen, Denmark

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  • Irwin Mclean,

    Affiliation: Population Pharmacogenetics Group, Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom

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  • Somnath Mukhopadhyay,

    Affiliation: Royal Alexandra Children's Hospital, Brighton and Sussex Medical School, Brighton, United Kingdom

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  • Christian B Pipper,

    Affiliation: Copenhagen Prospective Studies on Asthma in Childhood, Danish Paediatric Asthma Centre, Copenhagen, University Hospital Gentofte, Copenhagen, Denmark

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  • Liselotte B Halkjaer,

    Affiliation: Copenhagen Prospective Studies on Asthma in Childhood, Danish Paediatric Asthma Centre, Copenhagen, University Hospital Gentofte, Copenhagen, Denmark

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  • Brian Lipworth,

    Affiliation: Asthma and Allergy Research Group, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Scotland, United Kingdom

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  • Jenny Hankinson,

    Affiliation: School of Translational Medicine, University of Manchester, University Hospital of South Manchester National Health Service Foundation Trust, Manchester, United Kingdom

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  • Ashley Woodcock,

    Affiliation: School of Translational Medicine, University of Manchester, University Hospital of South Manchester National Health Service Foundation Trust, Manchester, United Kingdom

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  • Adnan Custovic

    Affiliation: School of Translational Medicine, University of Manchester, University Hospital of South Manchester National Health Service Foundation Trust, Manchester, United Kingdom

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  • Published: June 24, 2008
  • DOI: 10.1371/journal.pmed.0050131

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