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Research Article

TXNIP Regulates Peripheral Glucose Metabolism in Humans

  • Hemang Parikh,

    Affiliation: Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmö, Malmö, Sweden

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  • Emma Carlsson,

    Affiliations: Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmö, Malmö, Sweden, Steno Diabetes Center, Gentofte, Denmark

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  • William A Chutkow,

    Affiliation: Cardiovascular Division, Brigham and Women's Hospital, Cambridge, Massachusetts, United States of America

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  • Lovisa E Johansson,

    Affiliation: Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmö, Malmö, Sweden

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  • Heidi Storgaard,

    Affiliation: Steno Diabetes Center, Gentofte, Denmark

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  • Pernille Poulsen,

    Affiliation: Steno Diabetes Center, Gentofte, Denmark

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  • Richa Saxena,

    Affiliations: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Christine Ladd,

    Affiliation: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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  • P. Christian Schulze,

    Affiliation: Cardiovascular Division, Brigham and Women's Hospital, Cambridge, Massachusetts, United States of America

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  • Michael J Mazzini,

    Affiliation: Cardiovascular Division, Brigham and Women's Hospital, Cambridge, Massachusetts, United States of America

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  • Christine Bjørn Jensen,

    Affiliation: Steno Diabetes Center, Gentofte, Denmark

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  • Anna Krook,

    Affiliation: Department of Physiology and Pharmacology, Section Integrative Physiology, Karolinska Institute, Stockholm, Sweden

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  • Marie Björnholm,

    Affiliation: Department of Molecular Medicine and Surgical Sciences, Section Integrative Physiology, Karolinska Institutet, Stockholm, Sweden

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  • Hans Tornqvist,

    Affiliation: Diabetes Biology, Novo Nordisk A/S, Maaloev, Denmark

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  • Juleen R Zierath,

    Affiliation: Department of Molecular Medicine and Surgical Sciences, Section Integrative Physiology, Karolinska Institutet, Stockholm, Sweden

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  • Martin Ridderstråle,

    Affiliation: Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmö, Malmö, Sweden

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  • David Altshuler,

    Affiliations: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Richard T Lee,

    Affiliation: Cardiovascular Division, Brigham and Women's Hospital, Cambridge, Massachusetts, United States of America

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  • Allan Vaag,

    Affiliations: Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmö, Malmö, Sweden, Steno Diabetes Center, Gentofte, Denmark

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  • Leif C Groop mail,

    To whom correspondence should be addressed. E-mail: Leif.Groop@med.lu.se (LCG); vamsi@hms.harvard.edu (VKM)

    Affiliations: Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmö, Malmö, Sweden, Program in Molecular Medicine, Helsinki University, Helsinki, Finland

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  • Vamsi K Mootha mail

    To whom correspondence should be addressed. E-mail: Leif.Groop@med.lu.se (LCG); vamsi@hms.harvard.edu (VKM)

    Affiliations: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: May 01, 2007
  • DOI: 10.1371/journal.pmed.0040158

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