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Research Article

Population Pharmacokinetics of Artesunate and Dihydroartemisinin following Intra-Rectal Dosing of Artesunate in Malaria Patients

  • Julie A Simpson mail,

    To whom correspondence should be addressed. E-mail: julieas@unimelb.edu.au

    Affiliation: Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia

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  • Tsiri Agbenyega,

    Affiliation: School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

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  • Karen I Barnes,

    Affiliation: Division of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa

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  • Gianni Di Perri,

    Affiliation: Clinica di Malattie Infecttive, Ospedale Amedeo di Savoia, Torino, Italy

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  • Peter Folb,

    Affiliation: South African Medical Research Council, Tygerberg, South Africa

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  • Melba Gomes,

    Affiliation: UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, World Health Organization, Geneva, Switzerland

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  • Sanjeev Krishna,

    Affiliation: Division of Cellular and Molecular Medicine, Centre for Infection, University of London, London, United Kingdom

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  • Srivicha Krudsood,

    Affiliation: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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  • Sornchai Looareesuwan,

    Affiliation: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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  • Sharif Mansor,

    Affiliation: Centre for Drug Research, Universiti Sains Malaysia, Penang, Malaysia

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  • Helen McIlleron,

    Affiliation: Division of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa

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  • Raymond Miller,

    Affiliation: Pfizer Global Research and Development, Ann Arbor, Michigan, United States of America

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  • Malcolm Molyneux,

    Affiliation: Malawi-Liverpool-Wellcome Trust Clinical Research Programme and Malaria Project, College of Medicine, Blantyre, Malawi

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  • James Mwenechanya,

    Affiliation: Malawi-Liverpool-Wellcome Trust Clinical Research Programme and Malaria Project, College of Medicine, Blantyre, Malawi

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  • Visweswaran Navaratnam,

    Affiliation: Centre for Drug Research, Universiti Sains Malaysia, Penang, Malaysia

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  • Francois Nosten,

    Affiliations: Shoklo Malaria Research Unit, Mae-Sot, Tak, Thailand, Wellcome Trust Mahidol University Oxford Tropical Medicine Research Programme, Mahidol University, Bangkok, Thailand

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  • Piero Olliaro,

    Affiliations: UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, World Health Organization, Geneva, Switzerland, Centre for Tropical Medicine and Vaccinology, Churchill Hospital, University of Oxford, United Kingdom

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  • Lorrin Pang,

    Affiliation: Department of Health, Maui County, Hawaii, United States of America

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  • Isabela Ribeiro,

    Affiliation: UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, World Health Organization, Geneva, Switzerland

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  • Madalitso Tembo,

    Affiliation: Malawi-Liverpool-Wellcome Trust Clinical Research Programme and Malaria Project, College of Medicine, Blantyre, Malawi

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  • Michele van Vugt,

    Affiliations: Shoklo Malaria Research Unit, Mae-Sot, Tak, Thailand, Department of AIDS and Tropical Medicine, Amsterdam Medical Center, Amsterdam, Netherlands

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  • Steve Ward,

    Affiliation: Liverpool School of Tropical Medicine, Liverpool, United Kingdom

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  • Kris Weerasuriya,

    Affiliation: Regional Office for South-East Asia, World Health Organization, New Delhi, India

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  • Kyaw Win,

    Affiliation: State Peace and Development Council, Myanmar

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  • Nicholas J White

    Affiliations: Wellcome Trust Mahidol University Oxford Tropical Medicine Research Programme, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine and Vaccinology, Churchill Hospital, University of Oxford, United Kingdom

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  • Published: November 28, 2006
  • DOI: 10.1371/journal.pmed.0030444

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