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Research Article

MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia

  • Yana Pikman,

    Affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Benjamin H Lee,

    Affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Thomas Mercher,

    Affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Elizabeth McDowell,

    Affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Benjamin L Ebert,

    Affiliations: Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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  • Maricel Gozo,

    Affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Adam Cuker,

    Affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Gerlinde Wernig,

    Affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Sandra Moore,

    Affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Ilene Galinsky,

    Affiliation: Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Daniel J DeAngelo,

    Affiliation: Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Jennifer J Clark,

    Affiliation: Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Stephanie J Lee,

    Affiliation: Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Todd R Golub,

    Affiliations: Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Howard Hughes Medical Institute, Boston, Massachusetts, United States of America

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  • Martha Wadleigh,

    Affiliation: Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • D. Gary Gilliland,

    Affiliations: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Howard Hughes Medical Institute, Boston, Massachusetts, United States of America

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  • Ross L Levine mail

    To whom correspondence should be addressed. E-mail: ross_levine@dfci.harvard.edu

    Affiliations: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: July 18, 2006
  • DOI: 10.1371/journal.pmed.0030270

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