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Research Article

Persistent Amyloidosis following Suppression of Aβ Production in a Transgenic Model of Alzheimer Disease

  • Joanna L Jankowsky mail,

    To whom correspondence should be addressed. E-mail: jlj2@caltech.edu (JLJ); E-mail: borchelt@mbi.ufl.edu (DRB)

    Affiliations: Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Division of Biology, California Institute of Technology, Pasadena, California, United States of America

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  • Hilda H Slunt,

    Affiliation: Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    ¤ Current address: Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States of America

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  • Victoria Gonzales,

    Affiliation: Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Alena V Savonenko,

    Affiliation: Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Jason C Wen,

    Affiliation: Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Nancy A Jenkins,

    Affiliation: Mouse Cancer Genetics Program, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, Maryland, United States of America

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  • Neal G Copeland,

    Affiliation: Mouse Cancer Genetics Program, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, Maryland, United States of America

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  • Linda H Younkin,

    Affiliation: Mayo Clinic Jacksonville, Jacksonville, Florida, United States of America

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  • Henry A Lester,

    Affiliation: Division of Biology, California Institute of Technology, Pasadena, California, United States of America

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  • Steven G Younkin,

    Affiliation: Mayo Clinic Jacksonville, Jacksonville, Florida, United States of America

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  • David R Borchelt mail

    To whom correspondence should be addressed. E-mail: jlj2@caltech.edu (JLJ); E-mail: borchelt@mbi.ufl.edu (DRB)

    Affiliations: Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    ¤ Current address: Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States of America

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  • Published: November 15, 2005
  • DOI: 10.1371/journal.pmed.0020355

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