Research Article

Tuberculosis Incidence in Prisons: A Systematic Review

  • Iacopo Baussano mail,

    Affiliations: Cancer Epidemiology Unit, UPO “A.Avogadro” and CPO-Piemonte, Novara, Italy, Division of Epidemiology, Public Health and Primary Care, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, United Kingdom

  • Brian G. Williams,

    Affiliation: Stop TB Department, World Health Organization, Geneva, Switzerland

  • Paul Nunn,

    Affiliation: Stop TB Department, World Health Organization, Geneva, Switzerland

  • Marta Beggiato,

    Affiliation: Cancer Epidemiology Unit, UPO “A.Avogadro” and CPO-Piemonte, Novara, Italy

  • Ugo Fedeli,

    Affiliation: SER, Epidemiological Department, Veneto Region, Castelfranco Veneto, Italy

  • Fabio Scano

    Affiliation: Stop TB Department, World Health Organization, Geneva, Switzerland

  • Published: December 21, 2010
  • DOI: 10.1371/journal.pmed.1000381



Transmission of tuberculosis (TB) in prisons has been reported worldwide to be much higher than that reported for the corresponding general population.

Methods and Findings

A systematic review has been performed to assess the risk of incident latent tuberculosis infection (LTBI) and TB disease in prisons, as compared to the incidence in the corresponding local general population, and to estimate the fraction of TB in the general population attributable (PAF%) to transmission within prisons. Primary peer-reviewed studies have been searched to assess the incidence of LTBI and/or TB within prisons published until June 2010; both inmates and prison staff were considered. Studies, which were independently screened by two reviewers, were eligible for inclusion if they reported the incidence of LTBI and TB disease in prisons. Available data were collected from 23 studies out of 582 potentially relevant unique citations. Five studies from the US and one from Brazil were available to assess the incidence of LTBI in prisons, while 19 studies were available to assess the incidence of TB. The median estimated annual incidence rate ratio (IRR) for LTBI and TB were 26.4 (interquartile range [IQR]: 13.0–61.8) and 23.0 (IQR: 11.7–36.1), respectively. The median estimated fraction (PAF%) of tuberculosis in the general population attributable to the exposure in prisons for TB was 8.5% (IQR: 1.9%–17.9%) and 6.3% (IQR: 2.7%–17.2%) in high- and middle/low-income countries, respectively.


The very high IRR and the substantial population attributable fraction show that much better TB control in prisons could potentially protect prisoners and staff from within-prison spread of TB and would significantly reduce the national burden of TB. Future studies should measure the impact of the conditions in prisons on TB transmission and assess the population attributable risk of prison-to-community spread.

Please see later in the article for the Editors' Summary

Editors' Summary


Every year, nearly 10 million people develop tuberculosis (TB)—a contagious bacterial infection usually of the lungs—and nearly two million people die from the disease. TB is caused by Mycobacterium tuberculosis, which spreads in airborne droplets when people with the disease cough or sneeze. Most people infected with M. tuberculosis never become ill—their immune system contains the infection. However, the bacteria remain dormant (latent) within the body, and a latent TB infection (LTBI) can cause active disease many years after the initial infection if host immunity declines. The symptoms of TB include a persistent cough, weight loss, and night sweats. Infection with M. tuberculosis can be diagnosed using the tuberculin skin test; tests for TB itself include chest X-rays and sputum cultures (in which bacteriologists try to grow M. tuberculosis from sputum samples, mucus brought up from the lungs by coughing). TB can usually be cured by taking several powerful antibiotics daily for several months.

Why Was This Study Done?

Last century, global control efforts began to reduce the incidence (number of new cases in a population in a given time) and prevalence (the number of affected people in a population) of LTBI and TB in many countries. Now, the emergence of antibiotic-resistant bacterial strains is thwarting these efforts. Consequently, it is important to identify settings where TB transmission is particularly high. One such setting is thought to be prisons. In these facilities, overcrowding, late case detection, inadequate treatment, and poor implementation of infection control measures (including incomplete segregation of people with active TB) might increase the TB transmission rate. However, it is not known how many people in prison become infected with M. tuberculosis or develop TB each year compared to the general population nor what percentage of LTBI and TB in the general population is attributable to exposure to M. tuberculosis in prison (the population attributable fraction or PAF%). Here, the researchers undertake a systematic review (a study that uses predefined criteria to identify all the research on a given topic) to investigate the incidence of TB in prisons.

What Did the Researchers Do and Find?

The researchers identified 23 studies that reported the incidence of LTBI and/or TB in prisons among both staff and prisoners. They estimated the incidence of TB in relevant general populations using World Health Organization data; estimates of the incidence of LTBI in the general population came from the studies themselves. The researchers then calculated the ratio between the incidence rates for LTBI and TB in prison and in the general population (incidence rate ratios or IRRs) for each study. For both LTBI and TB, the IRR varied widely between studies. The average IRR for LTBI was 26.4. That is, the average incidence of LTBI in prisons was 26.4 times higher than in the general population; the average IRR for TB was 23.0. The researchers also estimated the fraction of TB in the general population attributable to within-prison exposure to M. tuberculosis for each study. Again, there was considerable heterogeneity between the studies but, on average, the PAF% for TB in high-income countries was 8.5% (that is, one in 11 cases of TB in the general population was attributable to within-prison spread of TB); in middle-to-low–income countries, the average PAF% was 6.3%.

What Do These Findings Mean?

These findings suggest that the risk of LTBI and TB is at least an order of magnitude higher in prisons than in the general population and that the within-prison spread of LTBI and TB is likely to substantially affect the incidence of LTBI and TB in the general population. The accuracy and generalizability of these findings are limited by the small number of studies identified, by the relative paucity of studies from countries other than the USA, by study heterogeneity, and by assumptions made in the calculation of PAF%. Even so, these findings suggest that improvements in TB control in prisons would not only help to protect prisoners and staff from within-prison spread of TB but would also reduce national TB burdens. Further studies are now needed to identify the specific conditions in prisons that influence TB transmission so that rational policies can be developed to improve TB control in correctional facilities.

Additional Information

Please access these Web sites via the online version of this summary at​000381.

  • This study is discussed in the December 2010 PLoS Medicine Editorial
  • The World Health Organization provides information on all aspects of TB, including information on TB in prisons and on the Stop TB Partnership (some information is in several languages)
  • The US Centers for Disease Control and Prevention has information about TB and on TB in prisons
  • The US National Institute of Allergy and Infectious Diseases also has detailed information on all aspects of TB


Occurrence of active tuberculosis (TB) in prisons is usually reported to be much higher than the average levels reported for the corresponding general population [1],[2]. In prisons located in developing countries TB has been reported as the most common cause of death [3]. High levels of TB in prison populations are likely to be attributable to the fact that a disproportionate number of prisoners are from population groups already at high risk of TB infection and TB disease (for example, alcohol or drug users, homeless people, mentally ill individuals, former prisoners, and illegal immigrants from areas characterized by high TB prevalence). Furthermore, the prison setting, where segregation criteria are based on crime characteristics rather than on public health concerns, may facilitate transmission. In addition, overcrowding, late case detection, inadequate treatment of infectious cases, high turnover of prisoners, and poor implementation of TB infection control measures are all known factors contributing to transmission of Mycobacterium tuberculosis. Finally, prisoners may be at risk of rapid progression of latent TB infection (LTBI) to TB disease following recent infection or reactivation of latent infection through coexisting pathology, particularly HIV infection, intravenous drug use, and poor nutritional status [3],[4].

Moreover, prisons represent a reservoir for disease transmission to the community at large; the TB infection may spread into the general population through prison staff, visitors, and close contacts of released prisoners [5]. The transmission dynamics between prisoners and the general population has been hypothesized to play a key role in driving overall population-level TB incidence, prevalence, and mortality rates [4].

Overlooking TB prevention and control in prisons settings can carry serious consequences for both prisoners and the general community, in particular in those countries where poor TB control, lack of TB infection control measures, and incarceration rates are high [3].

The main objectives of the present study were to assess, by reviewing the published literature, the consequences of within-prison spread of TB, estimating the relative risk and risk difference for incident latent TB infection (LTBI) and TB disease in prisons worldwide, as compared to the incidence in the corresponding local general population and the fraction (percent) of LTBI and TB in the general population attributable (PAF%) to the exposure in prisons. The aim of this study is to provide relative and absolute estimates of the risk of TB associated with incarceration, and of the potential impact of specific preventive measures to control TB transmission in the prison setting.


Search Strategy

An initial search of the available literature for systematic reviews or meta-analyses reporting estimates of the occurrence of LTBI and TB incidence in prisons did not identify potentially relevant studies. Details on the search strategy adopted to identify original primary studies in English, French, Italian, Spanish, Portuguese, or Russian, published since January 1980 through June 2010, and reporting data on the incidence of LTBI and TB in prisons, are reported in Text S2.

Study Selection

The PRISMA checklist is in Text S1. Studies were eligible for inclusion if they reported the incidence of LTBI and TB disease in prisons or if they reported the number of incident LTBI and TB cases identified in the study along with the overall number of inmates or prison personnel investigated or the person-years of follow-up. LTBI incidence has been defined as tuberculin conversion, that is newly positive tuberculin skin test (TST) after a documented negative-baseline TST as reported in the original study [6]. For TB disease incident cases we included both definitive (microbiologically confirmed) and presumptive (based on clinical, imaging, or pathology criteria) diagnoses. In order to include studies of comparable quality, we considered only data published in peer-reviewed journals. Thus data from unpublished literature, such as Ministry of Health or Justice reports, were not included.

We excluded studies with the following characteristics: (1) reporting only case series; (2) reporting only outbreak investigations; (3) reporting only prevalence of LTBI and TB in prisons; (4) reporting investigations targeted only to multi-drug resistant TB, (5) case-control studies, (6) those starting before 1980. All duplicate citations were eliminated from the initial database. Three reviewers screened these citations by reviewing titles and abstracts to identify potentially relevant studies. Disagreements between the reviewers were resolved by consensus. The database was then screened again to include only primary research articles, and the full text of each citation was obtained and reviewed.

Data Extraction

A data extraction form was designed by three reviewers, then all the papers were independently reviewed and data extraction was cross-checked. Disagreements between the reviewers were resolved by consensus.

The following datasets were collected from each study: country where the study was performed, study period, incidence of LTBI/TB and corresponding confidence intervals and/or the number of incident LTBI and TB cases identified, and the overall number of inmates or prison personnel investigated or the person-years of follow-up, and if reported the incidence of LTBI and/or TB in a comparison group, such as the local general population or prison administrative workers not exposed to TB in the setting under investigation.

To estimate TB incidence among the general populations in the host countries, we used estimates provided by the WHO for the corresponding study period (WHO Global Health Atlas [7]). To estimate LTBI incidence among the general populations in the host countries, we used estimates provided in the original papers or, alternatively, as reported in the literature.

Data Analysis

For each study the incidence rate ratio (IRR) for LTBI and TB in prison compared to the incidence in the general population was calculated. The presence of heterogeneity across studies was assessed by the conventional chi-squared test for heterogeneity (we regarded a p-level below 0.05 as indicating significant heterogeneity in the data), and by calculating the I2 statistic, which accounts for the number of studies included in the meta-analysis and provides a direct measure of the variability not explained by the information included in the analysis [8]. We used STATA version 9.2 (StataCorp, College Station, TX, USA) software for statistical analysis.

In order to assess the fraction of LTBI or TB in the population attributable to the exposure to prison settings, we calculated the population attributable fraction percent (PAF%) using Levin's formula [9] , where IRR is the LTBI or TB IRR measured from each study and Pe is the proportion of the population in prisons as given in the Human Development Report (year 2007/08) [10]. Other sources of information provide slightly different figures, for example those reported by the “International Centre for Prison Studies” of the King's College in London [11] are usually slightly higher than those reported by the United Nations [10]; however, the data from the two sources are consistent.

To investigate possible sources of heterogeneity, we stratified the analysis according to income of the population in which the study was conducted. In particular, we defined two strata, high- and middle/low-income countries as classified by the World Bank [12]. Furthermore, to investigate potential sources of heterogeneity, we tested, by means of univariate meta-regression analyses, the possible effect of between-study variance of overcrowding, presence/absence of ventilation systems, strategies of isolation of suspected TB cases, and TST testing at entry as reported in each study. We also tested the effect of study quality, which was assessed using the Newcastle-Ottawa scoring scale for cohort studies [13]. In brief, the quality of the studies was assessed considering the definition and representativeness of the cohort of inmates or prison personnel, the diagnostic criteria for cases of active TB, and the comparability of the cohorts on the basis of the study design or analysis.


The study selection process is shown in Figure 1. We identified 582 potentially relevant unique citations from all literature searches. From 256 original primary studies, 23 studies [14][36] were included, accounting overall for 670 cases of LTBI with 31,404 person-years of follow-up and for 1,710 cases of TB with 512,780 person-years of follow-up. Steenland et al. reported LTBI cases among prison personnel separately, according to their “high” or “low” risk of being exposed to inmate cases of TB cases [30]; Russkikh et al. reported TB incidence among prison personnel in Udmurt Republic (Russian Federation) during and following the socioeconomic crisis that occurred in Russia in the late 1990s [35]; whereas Klopf et al. reported TB incidence rates before and after the implementation of a TB control program in New York State Department of Correctional Services, separately [21]. We kept these distinctions in our analyses. None of the selected studies reported data from short-term correctional facilities.


Figure 1. Flow diagram for study selection.


The median number of cases per study of LTBI in prisons was 86 (interquartile range [IQR]: 49–169) and 68 for TB (IQR: 23–214), while the median number of person-years of follow-up in each study was 8,027 (IQR: 1,027–9,746) for LTBI and 13,869 (IQR: 3,927–81,759) for TB.

For studies reporting LTBI data collected since 1991, five studies were from the US (high-income country) and one study was from Brazil (middle-income country). For studies reporting TB data collected since 1981, 13 studies were from high-income countries, six studies were from countries with an estimated middle/low-income [16],[22],[29]. The geographic distribution of studies reporting TB incidence was more heterogeneous.

Tables 1 and 2 summarize the findings of the six and 19 studies that reported LTBI and TB incident cases in prisons, respectively. In particular, for each study included in the review, we have reported the period under investigation, the number of LTBI or TB cases and the person-years at risk, the LTBI or TB incidence for the comparison group representing the local general population, the estimated rate difference, the estimated IRR with the corresponding 95% confidence intervals (95%CIs), the incarcerated population (per 1,000 inhabitants), and the estimated PAF%.


Table 1. Studies reporting LTBI incidence in prisons.


Table 2. Studies reporting TB incidence in prisons, by income area according to the World Bank classification.


The median estimated annual incidence of LTBI in prisons was 2.6% (IQR: 1.3%–8.4%) overall and 2.1% (IQR: 1.3%–5.9%) for studies from the US. The IRR for LTBI was 26.4 (IQR: 13.0–61.8) overall and 21.6 (IQR: 13.0–59.1) for studies from the US. Figure 2 shows the distribution of the IRR for LTBI by income area.


Figure 2. Forest plot showing the study-specific estimates of the IRRs for LTBI in prisons as compared to corresponding general populations, by income area according to the World Bank classification.

Source: [12].


The median estimated annual incidence of TB in prisons was 237.6 per 100,000 persons (IQR: 156–639) for studies from high-income countries and 1,942.8 per 100,000 persons (IQR: 1,045.3–2,777.8) for studies from middle/low-income countries. The median estimated IRR for TB were 17.9 (IQR: 8.6–61) and 32.8 (IQR: 15.4–36.1), respectively. The median difference between annual incidence of LTBI measured in prisons as compared with that measured in the general population was 2.5% (IQR: 1.2%–8.3%).

Since all the studies reporting data about LTBI incidence in prisons from high-income countries were from the US, we restricted the analysis of TB incidence to studies from the US, in order to compare incidence ratio ratios for LTBI and TB. The calculated median estimate for TB was 48 (IQR: 24–114.5), which was higher than the IRR of 32 (IQR: 19.6–44.3) found for LTBI, though the distribution of these estimates largely overlapped (see above). Figure 3 shows the distribution of the IRR for TB by income area.


Figure 3. Forest plot showing the study-specific estimates of the IRR for tuberculosis in prisons as compared to the corresponding general populations, by income area according to the World Bank classification.

Source: [12]. NA, not applicable.


Finally, using the estimated annual incidence of LTBI and annual TB IRR and the reported population proportion of inmates for each country of interest we estimated the PAF%. The median population in prison (per 1,000 inhabitants) was 4.7 (IQR: 1.4–7.4) for high-income countries and 6.1 (IQR: 1.9–6.1) for middle/low-income countries.

The median estimated PAF% for LTBI was 13.1% (IQR: 8.1%–30.0%) for studies from high-income countries (US) and 10.4% for the only study from a middle-income country. The median estimated PAF% for TB was 8.5% (IQR: 1.9%–17.9%) for studies from high-income countries and 6.3% (IQR: 2.7%–17.2%) for studies from middle-low–income countries.

Figure 4 shows the PAF% (on a log scale) for TB as a function of both the proportion of population in prison and the IRR between prisoners and general population. As an example, Jones [20] and Koffi [22] reported similar IRRs—34 and 33 respectively—but due to the different proportions of the population that are in prison the estimated PAF% diverge widely (19.7% versus 1.5%). On the other hand, Fernandez de la Hoz and Wong [32] reported from countries with similar proportions of incarcerated population, 1.4 and 1.7 per 1000 population respectively, but the large difference in IRR produces a substantial shift in the estimated PAF% (4% versus 0.4%).


Figure 4. Contour plot showing the relationship between the proportion of exposed population, IRR, and PAF%.

X-axis reports the proportion of the population in prison, Y-axis reports the PAF on a log scale calculated using the Levin's formula [9]. The isoclines represent different levels of IRR. Klopf et al. reported TB incidence *before and **after implementation of a TB control program in New York State Department of Correctional Services and prisons personnel separately.[21] Russkikh et al. reported TB incidence among prison personnel during and following the socioeconomic crisis occurred in Russia in the late 1990s [35].


The between-study heterogeneity was considerable. In particular, the overall I2 statistic was 98% (95%CIs: 98%–99%); it was 98% (95%CIs: 97%–98%) for data from high-income countries and 94% (95%CIs: 87%–97%) for data from middle/low-income countries. The heterogeneity did not decrease significantly after stratification by income of the countries. Similarly, accounting in univariate metaregression analyses for overcrowding of the prison setting, presence/absence of ventilation systems, strategies of isolation of suspected TB cases, and TST or TB testing at entry into prison did not show any significant effect on decreasing the between-study variance. However, the IRR estimated from Wong et al. [32], the study with the highest quality scoring, differed significantly from the IRR estimated from studies with the lowest quality scoring. However, no other significant difference was attributable to studies' quality scoring.


In this study we attempt to summarize the published evidence of incidence of both LTBI and TB in prisons. The present systematic review confirms, using peer-reviewed data from both high- and middle/low-income countries, that the risk for TB is at least one order of magnitude greater in prisons than in the general population, as reported by Aerts et al. [37] in a questionnaire-based survey from the WHO European Region. Analogous results have been reported by Zarate et al. [38] in a review summarizing data from international organizations such as the International Committee of the Red Cross and the WHO.

The magnitudes of IRR for LTBI and TB estimated in the present systematic review are consistent with each other. Furthermore the finding that the median IRR for LTBI (26.4; IQR: 13.0–61.8) is comparable to that for TB (23.0; IQR: 11.7–36.1) is in line with findings from previous reports and suggests that incident TB cases have a greater impact on subsequent transmission than does importation of LTBI [39]. However, in settings where screening is performed at entry in prison, incident TB cases may represent some LTBI importation. Direct evidence, based on molecular genotyping and drug susceptibility testing, of TB transmission in prisons was recently provided by Matthys et al. [40].

Although in some countries the number of TB cases in prisons represents a relevant proportion of the overall burden of the disease, data on TB in prisons are not always reported to ministries of health [41]. Thus, the TB incidence statistics used for international reporting may be flawed. This underreporting may help to limit a potential bias in our estimates for the IRR (and therefore PAF%), with prisoners being compared to a truly unexposed population; by contrast, if in some countries data from prisons were merged with that of the general population, IRR could have been underestimated. However, those who enter and exit prisons are more likely to belong to population subgroups at a higher risk for LTBI and TB disease than the general population, such as illegal immigrants, hard-to-reach people (such as the homeless), and underserved ethnic-social minorities. A higher risk of transmission outside of the prisons with respect to the general population may lead to an overestimation of IRRs, since a fraction of the transmission occurring within the community would be attributed to the prison setting.

The PAF% values given here should be considered estimates of the real impact of transmission of TB within prisons, depicting the two main forces acting on such an impact: the proportion of the population in prison and the role of measures to control transmission. The method adopted to estimate the PAF% was developed to measure the impact on a population of risk factors for noncommunicable diseases [9] and does not account for the transmission dynamics of infectious diseases. In particular, it does not capture the indirect effects of preventive strategies devised to interrupt the chain of disease transmission. Thus, our estimates cannot capture the consequences of introducing TB control measures on transmission dynamics within a prison or between a prison and the local community [1]. Incarcerated people and prison staff can move to different institutions within the judiciary system and to health centers. Plus, prisoners and prison staff have contact with visitors, and prisoners can be freed without a diagnosis or before having completed therapy [3],[41]. As a consequence, not only have prison outbreaks of TB been linked to an increased incidence of TB in local communities, but mass incarceration in Central Asian and Eastern European countries has been associated with the increase of TB rates in the general population [4].

Education on early identification of TB and early case management, screening of inmates at arrival, isolation of cases with positive sputum smears—within the framework of community health services when necessary [5],[42]—all represent potentially effective measures. Their implementation is, however often hampered by resource constraints specific to the prison setting. Nevertheless, emphasis should always be placed on control of TB transmission, especially in periods of growth of prison populations [4].

In high- and middle/low-income countries, the maximum possible reduction of the median TB annual incidence in prisons was estimated to be 187 and 1,893 per 100,000 population, respectively. Although assessing the cost-effectiveness of the introduction of TB transmission control measures is beyond the scope of this paper, such a potential reduction of TB incidence in prisons would make attractive a range of infection control strategies.

The PAF% for TB and LTBI in high- and medium/low-income countries ranges from 4.5% to 10.4%; however, figures for high-income countries are driven by data from the US, the country with the largest prison population. Nonetheless, data from the US could provide useful insights into the epidemiology of TB in prisons: The IRRs for LTBI and TB are consistent. Furthermore, data reported by Klopf et al. [21] showed that a reduction of IRR from 25 to 6.8 may have halved the PAF% from 62.3% to 30.7%.

Unfortunately, there is a lack of data from Africa and Central Asia, so it is unclear to what extent these findings can be generalized to other countries, with factors such as inadequate nutrition and HIV prevalence [43] possibly playing substantial roles. Limited data from the Russian Federation seem to support our findings. A limitation of the present study is that few reviewed papers stratified the prison population for relevant risk factors such as HIV status.

The present findings should be interpreted in the light of some study limitations. The high heterogeneity between studies did not allow a pooled analysis of the data; similar levels of heterogeneity have been observed in other systematic reviews focusing on control of TB transmission and those analyzing observational studies [44],[45]. Such heterogeneity can be due to differences in methodological quality, study design, sampling variability, and study populations across studies. Unfortunately, the meta-regression analyses testing for the potential effect on the between-study heterogeneity of prison overcrowding, implementation of TB infection control interventions, strategies of isolation of suspected TB cases, TST or TB testing upon entry into prison, and study quality scoring did not show any significant role for these factors. In particular, we were unable to account for the duration of time that inmates spend in prisons. Furthermore, we could not account for specific patterns of incarceration, since the classification and organization of detention centers differ between countries.

It has been shown that the direct comparison of the TB rates estimated in prisons from the same area but with different characteristics may differ significantly [46]. Furthermore, the best available estimates of LTBI incidence in general population should be regarded cautiously, since they are not drawn from random samples of the population. Meanwhile, information on factors potentially affecting the TST result interpretation such as BCG (bacille Calmette-Guérin) status and nontuberculous mycobacteria distribution in the local population are not available.

The PAF% estimates given here rely on a few key assumptions that cannot be assessed directly. The first assumption is that the proportion of the population in prisons as reported by the Human Development Report [47] is reliable and applicable to the specific prison setting investigated in the reviewed studies. The second is that the IRR for TB remains relatively constant over time; in fact, fluctuations of the IRR may occur within a decade or more [48].

In conclusion, these findings provide a detailed summary of the evidence on LTBI and TB risk and incidence in prisons attributable to within-prison spread of TB and make it possible to estimate the impact at a population level. These data may prove useful to inform the development of rational policies to control TB transmission in correctional facilities. Future studies should assess the population attributable risk of prison-to-community spread and describe the conditions in the prison that influence TB transmission. Reporting on the factors potentially affecting the rates of transmission within the different prisons should reduce the heterogeneity of the reported findings and may help us understand the main reasons for the differences in transmission in different settings.

Supporting Information

Text S1.

PRISMA checklist.


(0.07 MB DOC)

Text S2.

Search details.


(0.02 MB DOC)


The authors are thankful to Natalia Budkevich, MD, who contributed substantially to the selection and analysis of papers written in Russian.

Author Contributions

ICMJE criteria for authorship read and met: IB BGW PN MB UF FS. Agree with the manuscript's results and conclusions: IB BGW PN MB UF FS. Designed the experiments/the study: IB BGW UF FS. Analyzed the data: IB MB FS. Collected data/did experiments for the study: IB MB UF. Wrote the first draft of the paper: IB. Contributed to the writing of the paper: IB BGW PN MB UF FS. Developed and supervised the area of work for the WHO policy on TB infection control, for which this paper formed one of the systematic reviews: PN.


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