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Research Article

Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development

  • Allison Jones equal contributor,

    equal contributor Contributed equally to this work with: Allison Jones, Andrew E. Teschendorff, Quanxi Li

    Affiliation: Department of Women's Cancer, UCL Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, United Kingdom

    X
  • Andrew E. Teschendorff equal contributor,

    equal contributor Contributed equally to this work with: Allison Jones, Andrew E. Teschendorff, Quanxi Li

    Affiliations: Statistical Cancer Genomics, UCL Cancer Institute, University College London, London, United Kingdom, CAS-MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai Institute for Biological Sciences, Shanghai, China

    X
  • Quanxi Li equal contributor,

    equal contributor Contributed equally to this work with: Allison Jones, Andrew E. Teschendorff, Quanxi Li

    Affiliation: Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

    X
  • Jane D. Hayward,

    Affiliation: Department of Women's Cancer, UCL Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, United Kingdom

    X
  • Athilakshmi Kannan,

    Affiliation: Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

    X
  • Tim Mould,

    Affiliation: Department of Women's Cancer, UCL Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, United Kingdom

    X
  • James West,

    Affiliations: Statistical Cancer Genomics, UCL Cancer Institute, University College London, London, United Kingdom, Centre for Mathematics and Physics in the Life Sciences and Experimental Biology, University College London, London, United Kingdom

    X
  • Michal Zikan,

    Affiliation: Gynaecologic Oncology Center, Department of Obstetrics and Gynaecology, First Faculty of Medicine and General University Hospital, Charles University Prague, Prague, Czech Republic

    X
  • David Cibula,

    Affiliation: Gynaecologic Oncology Center, Department of Obstetrics and Gynaecology, First Faculty of Medicine and General University Hospital, Charles University Prague, Prague, Czech Republic

    X
  • Heidi Fiegl,

    Affiliation: Department of Gynaecology and Obstetrics, Innsbruck Medical University, Innsbruck, Austria

    X
  • Shih-Han Lee,

    Affiliation: Department of Women's Cancer, UCL Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, United Kingdom

    X
  • Elisabeth Wik,

    Affiliations: Department of Obstetrics and Gynaecology, Haukeland University Hospital, Bergen, Norway, Center for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway

    X
  • Richard Hadwin,

    Affiliation: Department of Women's Cancer, UCL Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, United Kingdom

    X
  • Rupali Arora,

    Affiliation: Department of Pathology, UCL Cancer Institute, University College London, London, United Kingdom

    X
  • Charlotte Lemech,

    Affiliation: Department of Medical Oncology, UCL Cancer Institute, University College London, London, United Kingdom

    X
  • Henna Turunen,

    Affiliation: Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland

    X
  • Päivi Pakarinen,

    Affiliation: Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland

    X
  • Ian J. Jacobs,

    Affiliations: Department of Women's Cancer, UCL Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, United Kingdom, Faculty of Medical and Human Sciences, University of Manchester, Manchester, United Kingdom

    X
  • Helga B. Salvesen,

    Affiliations: Department of Obstetrics and Gynaecology, Haukeland University Hospital, Bergen, Norway, Center for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway

    X
  • Milan K. Bagchi,

    Affiliation: Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

    X
  • Indrani C. Bagchi,

    Affiliation: Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

    X
  • Martin Widschwendter mail

    M.Widschwendter@ucl.ac.uk

    Affiliation: Department of Women's Cancer, UCL Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, United Kingdom

    X
  • Published: November 12, 2013
  • DOI: 10.1371/journal.pmed.1001551

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