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Research Article

The Effect of Elevated Body Mass Index on Ischemic Heart Disease Risk: Causal Estimates from a Mendelian Randomisation Approach

  • Børge G. Nordestgaard equal contributor mail,

    equal contributor Contributed equally to this work with: Børge G. Nordestgaard, Tom M. Palmer

    Boerge.Nordestgaard@regionh.dk (BGN); n.j.timpson@bris.ac.uk (NJT)

    Affiliations: Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark, The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark, The Copenhagen City Heart Study, Bispebjerg Hospital, Copenhagen University Hospital, Copenhagen, Denmark, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Tom M. Palmer equal contributor,

    equal contributor Contributed equally to this work with: Børge G. Nordestgaard, Tom M. Palmer

    Affiliations: MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

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  • Marianne Benn,

    Affiliations: Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark, The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Jeppe Zacho,

    Affiliations: Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark, The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Anne Tybjærg-Hansen,

    Affiliations: The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark, The Copenhagen City Heart Study, Bispebjerg Hospital, Copenhagen University Hospital, Copenhagen, Denmark, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

    X
  • George Davey Smith,

    Affiliations: MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

    X
  • Nicholas J. Timpson mail

    Boerge.Nordestgaard@regionh.dk (BGN); n.j.timpson@bris.ac.uk (NJT)

    Affiliations: MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

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  • Published: May 01, 2012
  • DOI: 10.1371/journal.pmed.1001212

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