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Research Article

The Association of Factor V Leiden and Prothrombin Gene Mutation and Placenta-Mediated Pregnancy Complications: A Systematic Review and Meta-analysis of Prospective Cohort Studies

  • Marc A. Rodger mail,

    mrodger@ohri.ca

    Affiliations: Thrombosis Program, Division of Hematology, Departments of Medicine, Obstetrics and Gynecology and Epidemiology/Community Medicine, University of Ottawa, Ottawa, Ontario, Canada, Clinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada

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  • Marisol T. Betancourt,

    Affiliations: Thrombosis Program, Division of Hematology, Departments of Medicine, Obstetrics and Gynecology and Epidemiology/Community Medicine, University of Ottawa, Ottawa, Ontario, Canada, Clinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada

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  • Peter Clark,

    Affiliation: Department of Transfusion Medicine, Ninewells, Hospital and Medical School, Dundee, United Kingdom

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  • Pelle G. Lindqvist,

    Affiliation: Department of Obstetrics and Gynecology, Karolinska Hospital, Huddinge, Sweden

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  • Donna Dizon-Townson,

    Affiliation: National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network, Bethesda, Maryland

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  • Joanne Said,

    Affiliations: Department of Perinatal Medicine, The Royal Women's Hospital, Carlton, Victoria Australia, Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, Victoria, Australia

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  • Uri Seligsohn,

    Affiliation: The Amalia Biron Thrombosis and Hemostasis Research Institute, the Chaim Sheba Medical Center, Tel Hashomer, Israel

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  • Marc Carrier,

    Affiliations: Thrombosis Program, Division of Hematology, Departments of Medicine, Obstetrics and Gynecology and Epidemiology/Community Medicine, University of Ottawa, Ottawa, Ontario, Canada, Clinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada

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  • Ophira Salomon,

    Affiliation: The Amalia Biron Thrombosis and Hemostasis Research Institute, the Chaim Sheba Medical Center, Tel Hashomer, Israel

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  • Ian A. Greer

    Affiliation: Hull York Medical School, York, United Kingdom

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  • Published: June 15, 2010
  • DOI: 10.1371/journal.pmed.1000292

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