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Research Article

SLC2A9 Is a High-Capacity Urate Transporter in Humans

  • Mark J Caulfield equal contributor mail,

    equal contributor Contributed equally to this work with: Mark J Caulfield, Patricia B Munroe

    To whom correspondence should be addressed. E-mail: m.j.caulfield@qmul.ac.uk

    Affiliation: Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, United Kingdom

    X
  • Patricia B Munroe equal contributor,

    equal contributor Contributed equally to this work with: Mark J Caulfield, Patricia B Munroe

    Affiliation: Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, United Kingdom

    X
  • Deb O'Neill,

    Affiliation: Department of Physiology, University of Alberta, Edmonton, Alberta, Canada

    X
  • Kate Witkowska,

    Affiliation: Department of Physiology, University of Alberta, Edmonton, Alberta, Canada

    X
  • Fadi J Charchar,

    Affiliation: Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, United Kingdom

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  • Manuel Doblado,

    Affiliation: Department of Obstetrics and Gynaecology, Washington University in St Louis School of Medicine, St. Louis, Missouri, United States of America

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  • Sarah Evans,

    Affiliation: Department of Obstetrics and Gynaecology, Washington University in St Louis School of Medicine, St. Louis, Missouri, United States of America

    X
  • Susana Eyheramendy,

    Affiliation: Department of Statistics, Pontificia Universidad Católica de Chile, Santiago, Chile

    X
  • Abiodun Onipinla,

    Affiliation: Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, United Kingdom

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  • Philip Howard,

    Affiliation: Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, United Kingdom

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  • Sue Shaw-Hawkins,

    Affiliation: Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, United Kingdom

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  • Richard J Dobson,

    Affiliation: Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, United Kingdom

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  • Chris Wallace,

    Affiliation: Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, United Kingdom

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  • Stephen J Newhouse,

    Affiliation: Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, United Kingdom

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  • Morris Brown,

    Affiliation: Clinical Pharmacology Unit, University of Cambridge, Addenbrookes Hospital, Cambridge, United Kingdom

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  • John M Connell,

    Affiliation: Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom

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  • Anna Dominiczak,

    Affiliation: Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom

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  • Martin Farrall,

    Affiliation: Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom

    X
  • G. Mark Lathrop,

    Affiliation: Centre National de Génotypage, Evry, France

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  • Nilesh J Samani,

    Affiliations: Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, United Kingdom, Epidemiology and Public Health, University College, London, United Kingdom

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  • Meena Kumari,

    Affiliation: Epidemiology and Public Health, University College, London, United Kingdom

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  • Michael Marmot,

    Affiliation: Epidemiology and Public Health, University College, London, United Kingdom

    X
  • Eric Brunner,

    Affiliation: Epidemiology and Public Health, University College, London, United Kingdom

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  • John Chambers,

    Affiliation: National Heart Lung Institute and Epidemiology and Public Health, Imperial College, London, United Kingdom

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  • Paul Elliott,

    Affiliation: National Heart Lung Institute and Epidemiology and Public Health, Imperial College, London, United Kingdom

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  • Jaspal Kooner,

    Affiliation: National Heart Lung Institute and Epidemiology and Public Health, Imperial College, London, United Kingdom

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  • Maris Laan,

    Affiliation: Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia

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  • Elin Org,

    Affiliation: Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia

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  • Gudrun Veldre,

    Affiliations: Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia, Department of Cardiology, University of Tartu, Tartu, Estonia

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  • Margus Viigimaa,

    Affiliation: Centre of Cardiology, North Estonia Medical Centre, Tallinn, Estonia

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  • Francesco P Cappuccio,

    Affiliation: Cardiovascular Medicine and Epidemiology, Clinical Sciences Research Institute, University of Warwick Medical School, Clifford Bridge Road, Coventry, United Kingdom

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  • Chen Ji,

    Affiliation: Cardiovascular Medicine and Epidemiology, Clinical Sciences Research Institute, University of Warwick Medical School, Clifford Bridge Road, Coventry, United Kingdom

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  • Roberto Iacone,

    Affiliation: Department of Clinical and Experimental Medicine, Federico II University of Naples Medical School, Naples, Italy

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  • Pasquale Strazzullo,

    Affiliation: Department of Clinical and Experimental Medicine, Federico II University of Naples Medical School, Naples, Italy

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  • Kelle H Moley,

    Affiliation: Department of Obstetrics and Gynaecology, Washington University in St Louis School of Medicine, St. Louis, Missouri, United States of America

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  • Chris Cheeseman

    Affiliation: Department of Physiology, University of Alberta, Edmonton, Alberta, Canada

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  • Published: October 07, 2008
  • DOI: 10.1371/journal.pmed.0050197

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