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Research Article

Convergence of Mutation and Epigenetic Alterations Identifies Common Genes in Cancer That Predict for Poor Prognosis

  • Timothy A Chan,

    Affiliations: Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America, Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America

    ¤ Current address: Human Oncology and Pathogenesis Program and Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America

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  • Sabine Glockner,

    Affiliations: Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America, Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland, United States of America

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  • Joo Mi Yi,

    Affiliation: Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America

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  • Wei Chen,

    Affiliations: Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America, Predoctoral Training Program in Human Genetics, The Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Leander Van Neste,

    Affiliation: Department of Molecular Biotechnology, Ghent University, Ghent, Belgium

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  • Leslie Cope,

    Affiliation: Biometry and Clinical Trials Division, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America

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  • James G Herman,

    Affiliation: Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America

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  • Victor Velculescu,

    Affiliations: Ludwig Center for Cancer Genetics and Therapeutics, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America, Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America

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  • Kornel E Schuebel mail,

    To whom correspondence should be addressed. E-mail: sbaylin@jhmi.edu (SBB); kornels@jhmi.edu (KES); nahuja@jhmi.ed (NA)

    Affiliation: Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America

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  • Nita Ahuja mail,

    To whom correspondence should be addressed. E-mail: sbaylin@jhmi.edu (SBB); kornels@jhmi.edu (KES); nahuja@jhmi.ed (NA)

    Affiliations: Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America, Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland, United States of America

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  • Stephen B Baylin mail

    To whom correspondence should be addressed. E-mail: sbaylin@jhmi.edu (SBB); kornels@jhmi.edu (KES); nahuja@jhmi.ed (NA)

    Affiliations: Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America, Predoctoral Training Program in Human Genetics, The Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Published: May 27, 2008
  • DOI: 10.1371/journal.pmed.0050114

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