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Research Article

Statins Impair Antitumor Effects of Rituximab by Inducing Conformational Changes of CD20

  • Magdalena Winiarska,

    Affiliations: Department of Immunology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland, Department of Laboratory Diagnostics and Clinical Immunology, the Medical University of Warsaw, Warsaw, Poland

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  • Jacek Bil,

    Affiliation: Department of Immunology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland

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  • Ewa Wilczek,

    Affiliation: Department of Pathology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland

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  • Grzegorz M Wilczynski,

    Affiliation: Laboratory of Molecular and Systemic Neuromorphology, Nencki Institute of Experimental Biology, Warsaw, Poland

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  • Malgorzata Lekka,

    Affiliation: Department of Applied Spectroscopy, The Henryk Niewodniczanski Institute of Nuclear Physics, Krakow, Poland

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  • Patrick J Engelberts,

    Affiliation: Genmab, Utrecht, The Netherlands

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  • Wendy J. M Mackus,

    Affiliation: Genmab, Utrecht, The Netherlands

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  • Elzbieta Gorska,

    Affiliation: Department of Laboratory Diagnostics and Clinical Immunology, the Medical University of Warsaw, Warsaw, Poland

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  • Lukasz Bojarski,

    Affiliation: Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology, Warsaw, Poland

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  • Tomasz Stoklosa,

    Affiliation: Department of Immunology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland

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  • Dominika Nowis,

    Affiliation: Department of Immunology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland

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  • Zuzanna Kurzaj,

    Affiliation: Department of Immunology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland

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  • Marcin Makowski,

    Affiliation: Department of Immunology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland

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  • Eliza Glodkowska,

    Affiliation: Department of Immunology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland

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  • Tadeusz Issat,

    Affiliation: Department of Immunology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland

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  • Piotr Mrowka,

    Affiliation: Department of Immunology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland

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  • Witold Lasek,

    Affiliation: Department of Immunology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland

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  • Anna Dabrowska-Iwanicka,

    Affiliation: Department of Lymphoproliferative Disease, Maria Sklodowska-Curie Memorial Cancer Center, Institute of Oncology, Warsaw, Poland

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  • Grzegorz W Basak,

    Affiliation: Department of Hematology, Oncology and Internal Diseases, the Medical University of Warsaw, Warsaw, Poland

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  • Maria Wasik,

    Affiliation: Department of Laboratory Diagnostics and Clinical Immunology, the Medical University of Warsaw, Warsaw, Poland

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  • Krzysztof Warzocha,

    Affiliation: Institute of Hematology and Transfusion Medicine, Warsaw, Poland

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  • Maciej Sinski,

    Affiliation: Department of Internal Diseases, Hypertension and Vascular Disease, the Medical University of Warsaw, Warsaw, Poland

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  • Zbigniew Gaciong,

    Affiliation: Department of Internal Diseases, Hypertension and Vascular Disease, the Medical University of Warsaw, Warsaw, Poland

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  • Marek Jakobisiak,

    Affiliation: Department of Immunology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland

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  • Paul W. H. I Parren,

    Affiliation: Genmab, Utrecht, The Netherlands

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  • Jakub Golab mail

    To whom correspondence should be addressed. E-mail: jgolab@ib.amwaw.edu.pl

    Affiliation: Department of Immunology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland

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  • Published: March 25, 2008
  • DOI: 10.1371/journal.pmed.0050064

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