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Research Article

Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

  • Chad K Heazlewood equal contributor,

    equal contributor Contributed equally to this work with: Chad K Heazlewood, Matthew C Cook, Rajaraman Eri

    Affiliation: Mucin and IBD Research Teams, Mucosal Diseases Program, Mater Medical Research Institute, and the University of Queensland, Aubigny Place, Mater Health Services, South Brisbane, Queensland, Australia

    X
  • Matthew C Cook equal contributor,

    equal contributor Contributed equally to this work with: Chad K Heazlewood, Matthew C Cook, Rajaraman Eri

    Affiliation: Immunology and Inflammation Group, Phenomix Australia, Acton, Australia

    ¤ Current address: Australian National University Medical School, Canberra, Australia

    X
  • Rajaraman Eri equal contributor,

    equal contributor Contributed equally to this work with: Chad K Heazlewood, Matthew C Cook, Rajaraman Eri

    Affiliation: Mucin and IBD Research Teams, Mucosal Diseases Program, Mater Medical Research Institute, and the University of Queensland, Aubigny Place, Mater Health Services, South Brisbane, Queensland, Australia

    X
  • Gareth R Price,

    Affiliation: Molecular Genetics Team, Mater Medical Research Institute, and the University of Queensland, Aubigny Place, Mater Health Services, South Brisbane, Queensland, Australia

    X
  • Sharyn B Tauro,

    Affiliation: Mucin and IBD Research Teams, Mucosal Diseases Program, Mater Medical Research Institute, and the University of Queensland, Aubigny Place, Mater Health Services, South Brisbane, Queensland, Australia

    X
  • Douglas Taupin,

    Affiliation: Gastroenterology Unit, Canberra Hospital, Woden, Australia

    X
  • David J Thornton,

    Affiliation: Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

    X
  • Chin Wen Png,

    Affiliation: Mucin and IBD Research Teams, Mucosal Diseases Program, Mater Medical Research Institute, and the University of Queensland, Aubigny Place, Mater Health Services, South Brisbane, Queensland, Australia

    X
  • Tanya L Crockford,

    Affiliation: Nuffield Dept of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

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  • Richard J Cornall,

    Affiliation: Nuffield Dept of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

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  • Rachel Adams,

    Affiliation: Mucin and IBD Research Teams, Mucosal Diseases Program, Mater Medical Research Institute, and the University of Queensland, Aubigny Place, Mater Health Services, South Brisbane, Queensland, Australia

    X
  • Masato Kato,

    Affiliation: Dendritic Cell Program, Mater Medical Research Institute, Aubigny Place, Mater Health Services, South Brisbane, Queensland, Australia

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  • Keats A Nelms,

    Affiliation: Immunology and Inflammation Group, Phenomix Australia, Acton, Australia

    ¤ Current address: Australian National University Medical School, Canberra, Australia

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  • Nancy A Hong,

    Affiliation: Phenomix Corporation, San Diego, California, United States of America

    X
  • Timothy H. J Florin,

    Affiliation: Mucin and IBD Research Teams, Mucosal Diseases Program, Mater Medical Research Institute, and the University of Queensland, Aubigny Place, Mater Health Services, South Brisbane, Queensland, Australia

    X
  • Christopher C Goodnow,

    Affiliation: Division of Immunology and Genetics and Australian Phenomics Facility, John Curtin School of Medical Research, The Australian National University, Canberra, Australia

    X
  • Michael A McGuckin mail

    To whom correspondence should be addressed. E-mail: mmcguckin@mmri.mater.org.au

    Affiliation: Mucin and IBD Research Teams, Mucosal Diseases Program, Mater Medical Research Institute, and the University of Queensland, Aubigny Place, Mater Health Services, South Brisbane, Queensland, Australia

    X
  • Published: March 04, 2008
  • DOI: 10.1371/journal.pmed.0050054

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