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Research Article

Reducing Amyloid Plaque Burden via Ex Vivo Gene Delivery of an Aβ-Degrading Protease: A Novel Therapeutic Approach to Alzheimer Disease

  • Matthew L Hemming,

    Affiliation: Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Michaela Patterson,

    Affiliation: Neuroregeneration Laboratories, McLean Hospital and Harvard University Udall Parkinson's Disease Research Center of Excellence, Belmont, Massachusetts, United States of America

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  • Casper Reske-Nielsen,

    Affiliation: Neuroregeneration Laboratories, McLean Hospital and Harvard University Udall Parkinson's Disease Research Center of Excellence, Belmont, Massachusetts, United States of America

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  • Ling Lin,

    Affiliation: Neuroregeneration Laboratories, McLean Hospital and Harvard University Udall Parkinson's Disease Research Center of Excellence, Belmont, Massachusetts, United States of America

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  • Ole Isacson,

    Affiliation: Neuroregeneration Laboratories, McLean Hospital and Harvard University Udall Parkinson's Disease Research Center of Excellence, Belmont, Massachusetts, United States of America

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  • Dennis J Selkoe mail

    To whom correspondence should be addressed. E-mail: dselkoe@rics.bwh.harvard.edu

    Affiliation: Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: August 28, 2007
  • DOI: 10.1371/journal.pmed.0040262

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