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Research Article

Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target

  • Angela N Kuntz,

    Affiliation: Department of Biological Sciences, Illinois State University, Normal, Illinois, United States of America

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  • Elisabeth Davioud-Charvet,

    Affiliations: Biochemie-Zentrum der Universität Heidelberg, Heidelberg, Germany, Centre National de la Recherche Scientifique (CNRS), Paris, France

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  • Ahmed A Sayed,

    Affiliation: Department of Biological Sciences, Illinois State University, Normal, Illinois, United States of America

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  • Lindsay L Califf,

    Affiliation: Department of Biological Sciences, Illinois State University, Normal, Illinois, United States of America

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  • Jean Dessolin,

    Affiliations: Biochemie-Zentrum der Universität Heidelberg, Heidelberg, Germany, Institut Européen de Chimie et Biologie, CNRS UMR 5144, Bordeaux University, Pessac Cedex, France

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  • Elias S. J Arnér,

    Affiliation: Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

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  • David L Williams mail

    To whom correspondence should be addressed. E-mail: dlwilli@ilstu.edu

    Affiliation: Department of Biological Sciences, Illinois State University, Normal, Illinois, United States of America

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  • Published: June 19, 2007
  • DOI: 10.1371/journal.pmed.0040206

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