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Research Article

Polymorphisms, Mutations, and Amplification of the EGFR Gene in Non-Small Cell Lung Cancers

  • Masaharu Nomura,

    Affiliation: Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Hisayuki Shigematsu,

    Affiliation: Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Lin Li,

    Affiliation: Cancer Prevention Research, Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Makoto Suzuki,

    Affiliation: Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Takao Takahashi,

    Affiliation: Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Pila Estess,

    Affiliation: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Mark Siegelman,

    Affiliation: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Ziding Feng,

    Affiliation: Cancer Prevention Research, Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Harubumi Kato,

    Affiliation: First Department of Surgery, Tokyo Medical University, Tokyo, Japan

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  • Antonio Marchetti,

    Affiliation: Pathology Unit, Clinical Research Center, Center of Excellence on Aging, University Foundation, Chieti, Italy

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  • Jerry W Shay,

    Affiliation: Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Margaret R Spitz,

    Affiliation: Department of Epidemiology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

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  • Ignacio I Wistuba,

    Affiliation: Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

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  • John D Minna,

    Affiliations: Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Adi F Gazdar mail

    To whom correspondence should be addressed. E-mail: adi.gazdar@utsouthwestern.edu

    Affiliations: Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Published: April 24, 2007
  • DOI: 10.1371/journal.pmed.0040125

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