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Table of Contents: June 2008

COVER

Drug Development for Maternal Health.

Image Credit: Image by Valarie Apperson at Flickr.com
Issue Image

The PLoS Medicine editorial this month argues that there are currently few incentives to develop new treatments for maternal health, and that political will is needed to support alternative approaches to those driven by the market. The editorial cites an analysis published earlier this year in PLoS Medicine, which found that between 1980 and 2007 only 17 new drugs were under active development for maternal health indications—less than 3% of the pipeline in cardiovascular health (Fisk et al., e22).

The "Catch 22" of the lack of effective treatments for tropical diseases in pregnancy is examined in an essay in this issue (White et al., e133). Risk aversion, among other factors, has led to the exclusion of pregnant women from clinical trials. As such, the authors argue, we don't know enough about the suitability for pregnant women of even well-established drugs.

Essays

New Medicines for Tropical Diseases in Pregnancy: Catch-22

Nicholas J White, Rose M McGready, François H Nosten

Ethical Implications of Modifying Lethal Injection Protocols

Leonidas G Koniaris, Kenneth W Goodman, Jeremy Sugarman, Uzoezi Ozomaro, Jonathan Sheldon, Teresa A Zimmers

Perspectives

Health in Action

Policy Forum

Guidelines and Guidance

Guidelines for Reporting Health Research: The EQUATOR Network's Survey of Guideline Authors

Iveta Simera, Douglas G Altman, David Moher, Kenneth F Schulz, John Hoey

Research Articles

Multidrug-Resistant Plasmodium vivax Associated with Severe and Fatal Malaria: A Prospective Study in Papua, Indonesia

Emiliana Tjitra, Nicholas M Anstey, Paulus Sugiarto, Noah Warikar, Enny Kenangalem, Muhammad Karyana, Daniel A Lampah, Ric N Price

Characterizing the Epidemiological Transition in Mexico: National and Subnational Burden of Diseases, Injuries, and Risk Factors

Gretchen Stevens, Rodrigo H Dias, Kevin J. A Thomas, Juan A Rivera, Natalie Carvalho, Simón Barquera, Kenneth Hill, Majid Ezzati

The Safety of Adult Male Circumcision in HIV-Infected and Uninfected Men in Rakai, Uganda

Godfrey Kigozi, Ronald H Gray, Maria J Wawer, David Serwadda, Frederick Makumbi, Stephen Watya, Fred Nalugoda, Noah Kiwanuka, Lawrence H Moulton, Michael Z Chen, Nelson K Sewankambo, Fred Wabwire-Mangen, Melanie C Bacon, Renee Ridzon, Pius Opendi, Victor Sempijja, Absolom Settuba, Denis Buwembo, Valerian Kiggundu, Margaret Anyokorit, James Nkale, Nehemia Kighoma, Blake Charvat

Effect of a Brief Video Intervention on Incident Infection among Patients Attending Sexually Transmitted Disease Clinics

Lee Warner, Jeffrey D Klausner, Cornelis A Rietmeijer, C. Kevin Malotte, Lydia O'Donnell, Andrew D Margolis, Gregory L Greenwood, Doug Richardson, Shelley Vrungos, Carl R O'Donnell, Craig B Borkowf , for the Safe in the City Study Group

How Well Do Clinical Pain Assessment Tools Reflect Pain in Infants?

Rebeccah Slater, Anne Cantarella, Linda Franck, Judith Meek, Maria Fitzgerald

Gene-Environment Interaction in the Onset of Eczema in Infancy: Filaggrin Loss-of-Function Mutations Enhanced by Neonatal Cat Exposure

Hans Bisgaard, Angela Simpson, Colin N.A Palmer, Klaus Bønnelykke, Irwin Mclean, Somnath Mukhopadhyay, Christian B Pipper, Liselotte B Halkjaer, Brian Lipworth, Jenny Hankinson, Ashley Woodcock, Adnan Custovic

Improving Melanoma Classification by Integrating Genetic and Morphologic Features

Amaya Viros, Jane Fridlyand, Juergen Bauer, Konstantin Lasithiotakis, Claus Garbe, Daniel Pinkel, Boris C Bastian

A Mouse to Human Search for Plasma Proteome Changes Associated with Pancreatic Tumor Development

Vitor M Faca, Kenneth S Song, Hong Wang, Qing Zhang, Alexei L Krasnoselsky, Lisa F Newcomb, Ruben R Plentz, Sushma Gurumurthy, Mark S Redston, Sharon J Pitteri, Sandra R Pereira-Faca, Renee C Ireton, Hiroyuki Katayama, Veronika Glukhova, Douglas Phanstiel, Dean E Brenner, Michelle A Anderson, David Misek, Nathalie Scholler, Nicole D Urban, Matt J Barnett, Cim Edelstein, Gary E Goodman, Mark D Thornquist, Martin W McIntosh, Ronald A DePinho, Nabeel Bardeesy, Samir M Hanash

The Reno-Vascular A2B Adenosine Receptor Protects the Kidney from Ischemia

Almut Grenz, Hartmut Osswald, Tobias Eckle, Dan Yang, Hua Zhang, Zung Vu Tran, Karin Klingel, Katya Ravid, Holger K Eltzschig

A Mechanism for the Inhibition of Neural Progenitor Cell Proliferation by Cocaine

Chun-Ting Lee, Jia Chen, Teruo Hayashi, Shang-Yi Tsai, Joseph F Sanchez, Stacie L Errico, Rose Amable, Tsung-Ping Su, Ross H Lowe, Marilyn A Huestis, James Shen, Kevin G Becker, Herbert M Geller, William J Freed

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