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Table of Contents: April 2008

COVER

Transparency in the Conduct and Reporting of Research.

Image Credit: Globes at the Museum of Communication, Berlin, by tuppus
Issue Image

Transparency in the conduct and reporting of health research is the concern of this month's editorial, which announces the launch of the new Guidelines and Guidance section in PLoS Medicine. The section will include articles that raise awareness of new methodological approaches, community standards for reporting and carrying out research, and guides to approaching statistical and methodological issues. Proposals for papers to be considered for this section can be entered through our presubmission system.

PLoS Medicine has actively promoted standards to improve the conduct and quality of research, including papers detailing the STROBE guidelines for observational studies (von Elm, et al. e296; Vandenbroucke, et al. e297) and the CONSORT statement for abstracts of randomized controlled trials (Hopewell, et al. e20). As the editorial mentions, the new section is timely, given the inaugural meeting of the EQUATOR (Enhancing the Quality and Transparency of Health Research) network in June, an initiative to provide resources and training relating to good research reporting.

Perspectives

Health in Action

Progress in Vaccination against Haemophilus influenzae type b in the Americas

M. Carolina Danovaro-Holliday, Salvador Garcia, Ciro de Quadros, Gina Tambini, Jon K Andrus

Policy Forums

Improving Defences at the Portal of HIV Entry: Mucosal and Innate Immunity

Robin J Shattock, Barton F Haynes, Bali Pulendran, Jorge Flores, José Esparza , on behalf of a Working Group convened by the Global HIV Vaccine Enterprise

Chile's Neoliberal Health Reform: An Assessment and a Critique

Jean-Pierre Unger, Pierre De Paepe, Giorgio Solimano Cantuarias, Oscar Arteaga Herrera

Research in Complex Humanitarian Emergencies: The Médecins Sans Frontières/Epicentre Experience

Vincent Brown, Philippe J Guerin, Dominique Legros, Christophe Paquet, Bernard Pécoul, Alain Moren

Research Articles

Lifetime Prevalence of Mental Disorders in Lebanon: First Onset, Treatment, and Exposure to War

Elie G Karam, Zeina N Mneimneh, Hani Dimassi, John A Fayyad, Aimee N Karam, Soumana C Nasser, Somnath Chatterji, Ronald C Kessler

A Randomised, Blinded, Placebo-Controlled Trial in Dementia Patients Continuing or Stopping Neuroleptics (The DART-AD Trial)

Clive Ballard, Marisa Margallo Lana, Megan Theodoulou, Simon Douglas, Rupert McShane, Robin Jacoby, Katja Kossakowski, Ly-Mee Yu, Edmund Juszczak , on behalf of the Investigators DART AD

Long-Term Interleukin-6 Levels and Subsequent Risk of Coronary Heart Disease: Two New Prospective Studies and a Systematic Review

John Danesh, Stephen Kaptoge, Andrea G Mann, Nadeem Sarwar, Angela Wood, Sara B Angleman, Frances Wensley, Julian P. T Higgins, Lucy Lennon, Gudny Eiriksdottir, Ann Rumley, Peter H Whincup, Gordon D. O Lowe, Vilmundur Gudnason

Estimating Incidence from Prevalence in Generalised HIV Epidemics: Methods and Validation

Timothy B Hallett, Basia Zaba, Jim Todd, Ben Lopman, Wambura Mwita, Sam Biraro, Simon Gregson, J. Ties Boerma , on behalf of the ALPHA Network

MMP1 and MMP7 as Potential Peripheral Blood Biomarkers in Idiopathic Pulmonary Fibrosis

Ivan O Rosas, Thomas J Richards, Kazuhisa Konishi, Yingze Zhang, Kevin Gibson, Anna E Lokshin, Kathleen O Lindell, Jose Cisneros, Sandra D MacDonald, Annie Pardo, Frank Sciurba, James Dauber, Moises Selman, Bernadette R Gochuico, Naftali Kaminski

Cytological and Transcript Analyses Reveal Fat and Lazy Persister-Like Bacilli in Tuberculous Sputum

Natalie J Garton, Simon J Waddell, Anna L Sherratt, Su-Min Lee, Rebecca J Smith, Claire Senner, Jason Hinds, Kumar Rajakumar, Richard A Adegbola, Gurdyal S Besra, Philip D Butcher, Michael R Barer

In Vivo Response to Methotrexate Forecasts Outcome of Acute Lymphoblastic Leukemia and Has a Distinct Gene Expression Profile

Michael J Sorich, Nicolas Pottier, Deqing Pei, Wenjian Yang, Leo Kager, Gabriele Stocco, Cheng Cheng, John C Panetta, Ching-Hon Pui, Mary V Relling, Meyling H Cheok, William E Evans

Targeted Nanoparticles for Imaging Incipient Pancreatic Ductal Adenocarcinoma

Kimberly A Kelly, Nabeel Bardeesy, Rajesh Anbazhagan, Sushma Gurumurthy, Justin Berger, Herlen Alencar, Ronald A DePinho, Umar Mahmood, Ralph Weissleder