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Table of Contents: November 2007

Issue Image

This month's cover image, showing the treatment regimen of a patient coinfected with multi-drug resistant TB (MDR-TB) and HIV, links to a collection of three PLoS Medicine Policy Forum articles arising from the Médecins Sans Frontières Symposium "No Time to Wait: Overcoming the Gaps in TB Drug Development." For the first time in decades there is a TB drug pipeline, but the paucity of candidates is still cause for alarm (see Casenghi et al. e293). The long duration of current TB regimens, the high prevalence of HIV co-infection, and the emergence of drug-resistant TB underscore the need for new TB drugs, say Schluger et al. (e302) in their article on building TB clinical trials capacity in high-burden countries. The expansion of MDR-TB treatment programs provides the setting in which MDR-TB trials can be implemented, say Mitnick et al. (e292).

Editorial

The PLoS Medicine Debate

What Are the Benefits and Risks of Fitting Patients with Radiofrequency Identification Devices?

Mark Levine, Ben Adida, Kenneth Mandl, Isaac Kohane, John Halamka

Essay

Perspectives

Policy Forums

New Approaches to Filling the Gap in Tuberculosis Drug Discovery

Martina Casenghi, Stewart T Cole, Carl F Nathan

Building Clinical Trials Capacity for Tuberculosis Drugs in High-Burden Countries

Neil Schluger, Unni Karunakara, Christian Lienhardt, Thomas Nyirenda, Richard Chaisson

Randomized Trials to Optimize Treatment of Multidrug-Resistant Tuberculosis

Carole D Mitnick, Kenneth G Castro, Mark Harrington, Leonard V Sacks, William Burman

Clinical Trials and Medical Care: Defining the Therapeutic Misconception

Gail E Henderson, Larry R Churchill, Arlene M Davis, Michele M Easter, Christine Grady, Steven Joffe, Nancy Kass, Nancy M. P King, Charles W Lidz, Franklin G Miller, Daniel K Nelson, Jeffrey Peppercorn, Barbra Bluestone Rothschild, Pamela Sankar, Benjamin S Wilfond, Catherine R Zimmer

Research Articles

Validation of the Symptom Pattern Method for Analyzing Verbal Autopsy Data

Christopher J. L Murray, Alan D Lopez, Dennis M Feehan, Shanon T Peter, Gonghuan Yang

Estimating Population Cause-Specific Mortality Fractions from in-Hospital Mortality: Validation of a New Method

Christopher J. L Murray, Alan D Lopez, Jeremy T Barofsky, Chloe Bryson-Cahn, Rafael Lozano

Professional Uncertainty and Disempowerment Responding to Ethnic Diversity in Health Care: A Qualitative Study

Joe Kai, Jackie Beavan, Christina Faull, Lynne Dodson, Paramjit Gill, Angela Beighton

Controlling Endemic Cholera with Oral Vaccines

Ira M Longini Jr., Azhar Nizam, Mohammad Ali, Mohammad Yunus, Neeta Shenvi, John D Clemens

Impact of Artemisinin-Based Combination Therapy and Insecticide-Treated Nets on Malaria Burden in Zanzibar

Achuyt Bhattarai, Abdullah S Ali, S. Patrick Kachur, Andreas Mårtensson, Ali K Abbas, Rashid Khatib, Abdul-wahiyd Al-mafazy, Mahdi Ramsan, Guida Rotllant, Jan F Gerstenmaier, Fabrizio Molteni, Salim Abdulla, Scott M Montgomery, Akira Kaneko, Anders Björkman

Long-Term Clinical Protection from Falciparum Malaria Is Strongly Associated with IgG3 Antibodies to Merozoite Surface Protein 3

Christian Roussilhon, Claude Oeuvray, Christine Müller-Graf, Adama Tall, Christophe Rogier, Jean-François Trape, Michael Theisen, Aissatou Balde, Jean-Louis Pérignon, Pierre Druilhe

Evolution of Antiretroviral Drug Costs in Brazil in the Context of Free and Universal Access to AIDS Treatment

Amy S Nunn, Elize M Fonseca, Francisco I Bastos, Sofia Gruskin, Joshua A Salomon

Cholinesterase Inhibitors in Mild Cognitive Impairment: A Systematic Review of Randomised Trials

Roberto Raschetti, Emiliano Albanese, Nicola Vanacore, Marina Maggini