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Table of Contents: November 2009

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In this month's Editorial, the PLoS Medicine editors argue that there are signs of an evolving "malaria activism" that is akin to AIDS activism. There have been two "waves" of successful malaria activism, they say. In the first wave, activists highlighted the gap between the huge burden of malaria and the tiny amount of international development assistance dedicated to its control. Such advocacy helped motivate donors to increase their malaria commitments. The second wave focused on making sure that the extra funding was used to purchase highly efficacious artemisinin-based combination therapy (ACT) rather than monotherapies such as chloroquine, which are largely ineffective in Africa. It's now time, say the editors, for a "third wave" of activism, to highlight the widespread ACT stock-outs (shortages) across Africa, a crisis that can have deadly consequences.

Essays

Evaluating eHealth: How to Make Evaluation More Methodologically Robust

Richard James Lilford, Jo Foster, Mike Pringle

Neglected Diseases

Packages of Care for Dementia in Low- and Middle-Income Countries

Martin J. Prince, Daisy Acosta, Erico Castro-Costa, Jim Jackson, K. S. Shaji

Health in Action

Policy Forums

The Unintended Consequences of Clinical Trials Regulations

Alex D. McMahon, David I. Conway, Tom M. MacDonald, Gordon T. McInnes

Ethical Data Release in Genome-Wide Association Studies in Developing Countries

Michael Parker, Susan J. Bull, Jantina de Vries, Tsiri Agbenyega, Ogobara K. Doumbo, Dominic P. Kwiatkowski

Mandatory Disclosure of Pharmaceutical Industry-Funded Events for Health Professionals

Jane Robertson, Ray Moynihan, Emily Walkom, Lisa Bero, David Henry

Research Articles

Hip Fracture Incidence in Relation to Age, Menopausal Status, and Age at Menopause: Prospective Analysis

Emily Banks, Gillian K. Reeves, Valerie Beral, Angela Balkwill, Bette Liu, Andrew Roddam , for the Million Women Study Collaborators

Effects of Genital Ulcer Disease and Herpes Simplex Virus Type 2 on the Efficacy of Male Circumcision for HIV Prevention: Analyses from the Rakai Trials

Ronald H. Gray, David Serwadda, Aaron A. R. Tobian, Michael Z. Chen, Frederick Makumbi, Tara Suntoke, Godfrey Kigozi, Fred Nalugoda, Boaz Iga, Thomas C. Quinn, Lawrence H. Moulton, Oliver Laeyendecker, Steven J. Reynolds, Xiangrong Kong, Maria J. Wawer