Table of Contents: May 2008


The Trouble with Medical News Reporting.

Image Credit: Giovanni Maki, originally published as Figure 2 in Schwitzer G, Mudur G, Henry D, Wilson A, Goozner M, et al. (2005) What Are the Roles and Responsibilities of the Media in Disseminating Health Information? PLoS Med 2(7): e215 doi:10.1371/journal.pmed.0020215
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"Today's health reporters may have been covering crime last week and politics the week before," points out this month's PLoS Medicine editorial, which discusses the current state of health news reporting and the steps that can be taken to improve it. One initiative to monitor the quality of health reporting is, launched two years ago. In a Health in Action paper (Schwitzer, e95) published in this month's issue of PLoS Medicine, the publisher of, Gary Schwitzer, reports on the project's findings after the evaluation of 500 health news stories. And an essay (Moynihan et al., e106), also linked to the editorial, looks at how disease mongering—the corporate creation of new diseases in order to sell treatments—has become part of the global health debate.


Disease Mongering Is Now Part of the Global Health Debate

Ray Moynihan, Evan Doran, David Henry


Health in Action

Guidelines and Guidance

A User's Guide to the NINDS rt-PA Stroke Trial Database

Robert J Dachs, John H Burton, Jeremy Joslin

The Ancillary-Care Obligations of Medical Researchers Working in Developing Countries

Participants in the 2006 Georgetown University Workshop on the Ancillary-Care Obligations of Medical Researchers Working in Developing Countries

Research in Translation

Resisting Immune Exhaustion in HIV-1 Infection

Sarah Rowland-Jones, Thushan de Silva

Research Articles

Alcohol Sales and Risk of Serious Assault

Joel G Ray, Rahim Moineddin, Chaim M Bell, Deva Thiruchelvam, Maria Isabella Creatore, Piotr Gozdyra, Michael Cusimano, Donald A Redelmeier

Association of Prenatal and Childhood Blood Lead Concentrations with Criminal Arrests in Early Adulthood

John Paul Wright, Kim N Dietrich, M. Douglas Ris, Richard W Hornung, Stephanie D Wessel, Bruce P Lanphear, Mona Ho, Mary N Rae

Decreased Brain Volume in Adults with Childhood Lead Exposure

Kim M Cecil, Christopher J Brubaker, Caleb M Adler, Kim N Dietrich, Mekibib Altaye, John C Egelhoff, Stephanie Wessel, Ilayaraja Elangovan, Richard Hornung, Kelly Jarvis, Bruce P Lanphear

Synergistic Effects of Hypofibrinolysis and Genetic and Acquired Risk Factors on the Risk of a First Venous Thrombosis

Mirjam E Meltzer, Ton Lisman, Carine J. M Doggen, Philip G de Groot, Frits R Rosendaal

Expectations for Recovery Important in the Prognosis of Whiplash Injuries

Lena W Holm, Linda J Carroll, J. David Cassidy, Eva Skillgate, Anders Ahlbom

Impact of Round-the-Clock, Rapid Oral Fluid HIV Testing of Women in Labor in Rural India

Nitika Pant Pai, Ritu Barick, Jacqueline P Tulsky, Poonam V Shivkumar, Deborah Cohan, Shriprakash Kalantri, Madhukar Pai, Marina B Klein, Shakuntala Chhabra

Pharmacy Refill Adherence Compared with CD4 Count Changes for Monitoring HIV-Infected Adults on Antiretroviral Therapy

Gregory P Bisson, Robert Gross, Scarlett Bellamy, Jesse Chittams, Michael Hislop, Leon Regensberg, Ian Frank, Gary Maartens, Jean B Nachega

Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1–Specific CD8+ T Cells

Hendrik Streeck, Zabrina L Brumme, Michael Anastario, Kristin W Cohen, Jonathan S Jolin, Angela Meier, Chanson J Brumme, Eric S Rosenberg, Galit Alter, Todd M Allen, Bruce D Walker, Marcus Altfeld

A Novel Tumor-Promoting Function Residing in the 5′ Non-coding Region of vascular endothelial growth factor mRNA

Kiyoshi Masuda, Shigetada Teshima-Kondo, Mina Mukaijo, Naoko Yamagishi, Yoshiko Nishikawa, Kensei Nishida, Tomoko Kawai, Kazuhito Rokutan

Convergence of Mutation and Epigenetic Alterations Identifies Common Genes in Cancer That Predict for Poor Prognosis

Timothy A Chan, Sabine Glockner, Joo Mi Yi, Wei Chen, Leander Van Neste, Leslie Cope, James G Herman, Victor Velculescu, Kornel E Schuebel, Nita Ahuja, Stephen B Baylin