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Table of Contents: March 2008

COVER

Network Theory and Medicine.

Image Credit: Image by Matt Britt, using data from the Opte Project
Issue Image

The image this month is a map of the Internet created by Matt Britt from data from the Opte Project. The closeup shows how nodes representing Internet addresses are connected (see the description in Wikimedia Commons).

The image relates to the theme of the editorial: network theory and how it is increasingly used to understand connections and relationships in health and medicine, whether at a cellular, population, or social level. In a paper on the dynamics of influenza transmission published this month (Mossong, et al. e74), network analysis helped the authors produce a mathematical model suggesting that 5- to 19-year-olds will suffer the highest burden of respiratory infection during any initial spread. Another paper (Lewis, et al. e50) using phylodynamics—a mix of genetics, epidemiology, and evolutionary biology—elucidated a transmission network that provides insights into HIV prevention.

The PLoS Medicine Debate

Essays

Late-Life Cardiac Interventions and the Treatment Imperative

Janet K Shim, Ann J Russ, Sharon R Kaufman

Perspectives

Inferring HIV Transmission Dynamics from Phylogenetic Sequence Relationships

Christopher D Pilcher, Joseph K Wong, Satish K Pillai

Policy Forums

Defining Challenges and Proposing Solutions for Control of the Virus Vector Aedes aegypti

Amy C Morrison, Emily Zielinski-Gutierrez, Thomas W Scott, Ronald Rosenberg

Syndromic Surveillance: Adapting Innovations to Developing Settings

Jean-Paul Chretien, Howard S Burkom, Endang R Sedyaningsih, Ria P Larasati, Andres G Lescano, Carmen C Mundaca, David L Blazes, Cesar V Munayco, Jacqueline S Coberly, Raj J Ashar, Sheri H Lewis

Research in Translation

Research Articles

Social Contacts and Mixing Patterns Relevant to the Spread of Infectious Diseases

Joël Mossong, Niel Hens, Mark Jit, Philippe Beutels, Kari Auranen, Rafael Mikolajczyk, Marco Massari, Stefania Salmaso, Gianpaolo Scalia Tomba, Jacco Wallinga, Janneke Heijne, Malgorzata Sadkowska-Todys, Magdalena Rosinska, W. John Edmunds

Episodic Sexual Transmission of HIV Revealed by Molecular Phylodynamics

Fraser Lewis, Gareth J Hughes, Andrew Rambaut, Anton Pozniak, Andrew J. Leigh Brown

Multidisciplinary Prospective Study of Mother-to-Child Chikungunya Virus Infections on the Island of La Réunion

Patrick Gérardin, Georges Barau, Alain Michault, Marc Bintner, Hanitra Randrianaivo, Ghassan Choker, Yann Lenglet, Yasmina Touret, Anne Bouveret, Philippe Grivard, Karin Le Roux, Séverine Blanc, Isabelle Schuffenecker, Thérèse Couderc, Fernando Arenzana-Seisdedos, Marc Lecuit, Pierre-Yves Robillard

An Antibiotic-Responsive Mouse Model of Fulminant Ulcerative Colitis

Silvia S Kang, Seth M Bloom, Lyse A Norian, Michael J Geske, Richard A Flavell, Thaddeus S Stappenbeck, Paul M Allen

Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

Chad K Heazlewood, Matthew C Cook, Rajaraman Eri, Gareth R Price, Sharyn B Tauro, Douglas Taupin, David J Thornton, Chin Wen Png, Tanya L Crockford, Richard J Cornall, Rachel Adams, Masato Kato, Keats A Nelms, Nancy A Hong, Timothy H. J Florin, Christopher C Goodnow, Michael A McGuckin

Global Transcript Profiles of Fat in Monozygotic Twins Discordant for BMI: Pathways behind Acquired Obesity

Kirsi H Pietiläinen, Jussi Naukkarinen, Aila Rissanen, Juha Saharinen, Pekka Ellonen, Heli Keränen, Anu Suomalainen, Alexandra Götz, Tapani Suortti, Hannele Yki-Järvinen, Matej Orešič, Jaakko Kaprio, Leena Peltonen

Exploring the Developmental Overnutrition Hypothesis Using Parental–Offspring Associations and FTO as an Instrumental Variable

Debbie A Lawlor, Nicholas J Timpson, Roger M Harbord, Sam Leary, Andy Ness, Mark I McCarthy, Timothy M Frayling, Andrew T Hattersley, George Davey Smith

Increased Microerythrocyte Count in Homozygous α+-Thalassaemia Contributes to Protection against Severe Malarial Anaemia

Freya J. I Fowkes, Stephen J Allen, Angela Allen, Michael P Alpers, David J Weatherall, Karen P Day

Statins Impair Antitumor Effects of Rituximab by Inducing Conformational Changes of CD20

Magdalena Winiarska, Jacek Bil, Ewa Wilczek, Grzegorz M Wilczynski, Malgorzata Lekka, Patrick J Engelberts, Wendy J. M Mackus, Elzbieta Gorska, Lukasz Bojarski, Tomasz Stoklosa, Dominika Nowis, Zuzanna Kurzaj, Marcin Makowski, Eliza Glodkowska, Tadeusz Issat, Piotr Mrowka, Witold Lasek, Anna Dabrowska-Iwanicka, Grzegorz W Basak, Maria Wasik, Krzysztof Warzocha, Maciej Sinski, Zbigniew Gaciong, Marek Jakobisiak, Paul W. H. I Parren, Jakub Golab

Correction

Correction: Combined Impact of Health Behaviours and Mortality in Men and Women: The EPIC-Norfolk Prospective Population Study

Kay-Tee Khaw, Nicholas Wareham, Sheila Bingham, Ailsa Welch, Robert Luben, Nicholas Day