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Table of Contents: June 2006

COVER

Different Approaches to Snake Bites.

Image Credit: Images taken from Wagstaff et al. and Gutiérrez et al.
Issue Image

The cover image brings together two papers in this month's PLoS Medicine that highlight the issue of snake bites. In a research article, Simon Wagstaff and colleagues describe the use of bioinformatics to design multiepitope DNA immunogens to make snake antivenom. And in a Neglected Diseases article, José María Gutiérrez and colleagues review the public health implications of snake bites.

Editorial

The Impact Factor Game

The PLoS Medicine Editors

Essays

The Limits of Reductionism in Medicine: Could Systems Biology Offer an Alternative?

Andrew C Ahn, Muneesh Tewari, Chi-Sang Poon, Russell S Phillips

Sacred Cows and Sympathetic Squirrels: The Importance of Biological Diversity to Human Health

Andy Dobson, Isabella Cattadori, Robert D Holt, Richard S Ostfeld, Felicia Keesing, Kristle Krichbaum, Jason R Rohr, Sarah E Perkins, Peter J Hudson

Neglected Diseases

Confronting the Neglected Problem of Snake Bite Envenoming: The Need for a Global Partnership

José María Gutiérrez, R. David G Theakston, David A Warrell

Perspectives

Health in Action

The Roulette Wheel: An Aid to Informed Decision Making

Jerome R Hoffman, Michael S Wilkes, Frank C Day, Douglas S Bell, Jerilyn K Higa

The Commission on Social Determinants of Health: Tackling the Social Roots of Health Inequities

Alec Irwin, Nicole Valentine, Chris Brown, Rene Loewenson, Orielle Solar, Hilary Brown, Theadora Koller, Jeanette Vega

Policy Forums

Manslaughter by Fake Artesunate in Asia—Will Africa Be Next?

Paul N Newton, Rose McGready, Facundo Fernandez, Michael D Green, Manuela Sunjio, Carinne Bruneton, Souly Phanouvong, Pascal Millet, Christopher J. M Whitty, Ambrose O Talisuna, Stephane Proux, Eva Maria Christophel, Grace Malenga, Pratap Singhasivanon, Kalifa Bojang, Harparkash Kaur, Kevin Palmer, Nicholas P. J Day, Brian M Greenwood, François Nosten, Nicholas J White

Getting It Right: Being Smarter about Clinical Trials

Barnett S Kramer, Joan Wilentz, Duane Alexander, John Burklow, Lawrence M Friedman, Richard Hodes, Ruth Kirschstein, Amy Patterson, Griffin Rodgers, Stephen E Straus

Advertising in Medical Journals: Should Current Practices Change?

Adriane Fugh-Berman, Karen Alladin, Jarva Chow

Pandemic Influenza: Risk of Multiple Introductions and the Need to Prepare for Them

Christina E Mills, James M Robins, Carl T Bergstrom, Marc Lipsitch

The National Security Implications of HIV/AIDS

Harley Feldbaum, Kelley Lee, Preeti Patel

Student Forum

Case Report

Mitral Stenosis Presenting with Acute Hearing Loss

Chamutal Gur, Gadi Lalazar, Guy Raphaeli, Dan Gilon, Eldad Ben-Chetrit

Research Articles

Rational Prescribing in Primary Care (RaPP): A Cluster Randomized Trial of a Tailored Intervention

Atle Fretheim, Andrew D Oxman, Kari Håvelsrud, Shaun Treweek, Doris T Kristoffersen, Arild Bjørndal

Does Random Treatment Assignment Cause Harm to Research Participants?

Cary P Gross, Harlan M Krumholz, Gretchen Van Wye, Ezekiel J Emanuel, David Wendler

Mass Fatality Management following the South Asian Tsunami Disaster: Case Studies in Thailand, Indonesia, and Sri Lanka

Oliver W Morgan, Pongruk Sribanditmongkol, Clifford Perera, Yeddi Sulasmi, Dana Van Alphen, Egbert Sondorp

Improving Imperfect Data from Health Management Information Systems in Africa Using Space–Time Geostatistics

Peter W Gething, Abdisalan M Noor, Priscilla W Gikandi, Esther A. A Ogara, Simon I Hay, Mark S Nixon, Robert W Snow, Peter M Atkinson

Bioinformatics and Multiepitope DNA Immunization to Design Rational Snake Antivenom

Simon C Wagstaff, Gavin D Laing, R. David G Theakston, Christina Papaspyridis, Robert A Harrison

Delaying the International Spread of Pandemic Influenza

Ben S Cooper, Richard J Pitman, W. John Edmunds, Nigel J Gay

Deployment of Early Diagnosis and Mefloquine- Artesunate Treatment of Falciparum Malaria in Thailand: The Tak Malaria Initiative

Verena Ilona Carrara, Supakit Sirilak, Janjira Thonglairuam, Chaiporn Rojanawatsirivet, Stephane Proux, Valery Gilbos, Al Brockman, Elizabeth A Ashley, Rose McGready, Srivicha Krudsood, Somjai Leemingsawat, Sornchai Looareesuwan, Pratap Singhasivanon, Nicholas White, François Nosten

Immune Protection of Nonhuman Primates against Ebola Virus with Single Low-Dose Adenovirus Vectors Encoding Modified GPs

Nancy J Sullivan, Thomas W Geisbert, Joan B Geisbert, Devon J Shedlock, Ling Xu, Laurie Lamoreaux, Jerome H. H. V Custers, Paul M Popernack, Zhi-Yong Yang, Maria G Pau, Mario Roederer, Richard A Koup, Jaap Goudsmit, Peter B Jahrling, Gary J Nabel

ApoE Plasma Levels and Risk of Cardiovascular Mortality in Old Age

Simon P Mooijaart, Jimmy F. P Berbée, Diana van Heemst, Louis M Havekes, Anton J. M de Craen, P. Eline Slagboom, Patrick C. N Rensen, Rudi G. J Westendorp

Acute-Phase Serum Amyloid A: An Inflammatory Adipokine and Potential Link between Obesity and Its Metabolic Complications

Rong-Ze Yang, Mi-Jeong Lee, Hong Hu, Toni I Pollin, Alice S Ryan, Barbara J Nicklas, Soren Snitker, Richard B Horenstein, Kristen Hull, Nelson H Goldberg, Andrew P Goldberg, Alan R Shuldiner, Susan K Fried, Da-Wei Gong

Linkage Disequilibrium Mapping of CHEK2: Common Variation and Breast Cancer Risk

Kristjana Einarsdóttir, Keith Humphreys, Carine Bonnard, Juni Palmgren, Mark M Iles, Arvid Sjölander, Yuqing Li, Kee Seng Chia, Edison T Liu, Per Hall, Jianjun Liu, Sara Wedrén

Lentiviral Expression of Retinal Guanylate Cyclase-1 (RetGC1) Restores Vision in an Avian Model of Childhood Blindness

Melissa L Williams, Jason E Coleman, Shannon E Haire, Tomas S Aleman, Artur V Cideciyan, Izabel Sokal, Krzysztof Palczewski, Samuel G Jacobson, Susan L Semple-Rowland

Labor-Associated Gene Expression in the Human Uterine Fundus, Lower Segment, and Cervix

Radek Bukowski, Gary D. V Hankins, George R Saade, Garland D Anderson, Steven Thornton

Correspondence

Investing in Exposure

Abdul Moiz Khan

Authors' Reply

Jocelyn E Mackie, Andrew D Taylor, David L Finegold, Abdallah S Daar, Peter A Singer

To Fully Tackle the Gang of Four, Needs-Driven R & D Is Essential

Els Torreele, Catherine Royce, Robert Don, Ann-Marie Sevcsik, Simon Croft

Response from Savioli and Colleagues from the Department of Neglected Tropical Diseases, World Health Organization

Lorenzo Savioli, Dirk Engels, Denis Daumerie, Jean Jannin, Jorge Alvar, Kingsley Asiedu, Marc Gastellu-Etchegorry, Pere Simarro, Silvio P Mariotti

Author's Reply

Richard L Kravitz